Homo sapiens Gene: FUS
Summary
InnateDB Gene IDBG-27917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUS
Gene Name fused in sarcoma
Synonyms ALS6; ETM4; FUS1; HNRNPP2; POMP75; TLS;
Species Homo sapiens
Ensembl Gene ENSG00000089280
Encoded Proteins
fused in sarcoma
fused in sarcoma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31180110-31194871
Strand Forward strand
Band p11.2
Transcripts
ENST00000254108 ENSP00000254108
ENST00000380244 ENSP00000369594
ENST00000487045
ENST00000487974
ENST00000474990
ENST00000487509
ENST00000483853
ENST00000568685 ENSP00000455282
ENST00000570090
ENST00000564766
ENST00000569760
ENST00000566605 ENSP00000455073
ENST00000568901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 319 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 319 [view]
Protein-Protein 318 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008219 cell death
GO:0008380 RNA splicing
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P35637
TrEMBL H3BNZ4 H3BPE7 Q6IBQ5
UniProt Splice Variant
Entrez Gene 2521
UniGene Hs.46894 Hs.609190 Hs.707575 Hs.724154
RefSeq NM_001170634 NM_001170937 NM_004960 XM_005255233
HUGO HGNC:4010
OMIM 137070
CCDS CCDS10707 CCDS58454
HPRD
IMGT
EMBL AC009088 AF071213 AJ295163 BC000402 BC002459 BT007131 CH471192 CR456747 S62138 S62140 X71427 X71428
GenPept AAB27102 AAB27103 AAC35284 AAC35285 AAH00402 AAH02459 AAP35795 CAA50558 CAA50559 CAC15058 CAG33028 EAW52150
RNA Seq Atlas 2521