Version 5.4
Homo sapiens Gene: KLF11
Summary
InnateDB Gene IDBG-28160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF11
Gene Name Kruppel-like factor 11
Synonyms FKLF; FKLF1; MODY7; TIEG2; Tieg3
Species Homo sapiens
Ensembl Gene ENSG00000172059
Encoded Proteins
IDBP-28162
Kruppel-like factor 11
IDBP-292748
Kruppel-like factor 11
IDBP-363248
Kruppel-like factor 11
IDBP-363249
Kruppel-like factor 11
IDBP-591386
Kruppel-like factor 11
IDBP-586425
Kruppel-like factor 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:10042849-10054836
Strand Forward strand
Band p25.1
Transcripts
ENST00000305883 ENSP00000307023
ENST00000401510 ENSP00000386058
ENST00000448523 ENSP00000387866
ENST00000440320 ENSP00000388263
ENST00000540845 ENSP00000444690
ENST00000535335 ENSP00000442722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020653
View Gene Order
ENSBTAG00000046218
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O14901
TrEMBL B5MCC4 C9JM94 E7EX78 Q53QU8
UniProt Splice Variant
Entrez Gene 8462
UniGene Hs.12229 Hs.694968
RefSeq NM_001177716 NM_001177718 NM_003597 XM_005246179
HUGO HGNC:11811
OMIM 603301
CCDS CCDS1668 CCDS54333
HPRD
IMGT
EMBL AC104794 AF028008 AF272830 AK289816 AK302880 BC063286 BC069383 BC074922 CH471053
GenPept AAC61880 AAF75793 AAH63286 AAH69383 AAH74922 AAX93098 BAF82505 BAG64059 EAX00972
RNA Seq Atlas 8462

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca