Homo sapiens Gene: DNM2
Summary
InnateDB Gene IDBG-28168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNM2
Gene Name dynamin 2
Synonyms CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; DYNII; LCCS5;
Species Homo sapiens
Ensembl Gene ENSG00000079805
Encoded Proteins
dynamin 2
dynamin 2
dynamin 2
dynamin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10718079-10833488
Strand Forward strand
Band p13.2
Transcripts
ENST00000355667 ENSP00000347890
ENST00000359692 ENSP00000352721
ENST00000389253 ENSP00000373905
ENST00000408974 ENSP00000386192
ENST00000591819
ENST00000587991
ENST00000587329
ENST00000588976
ENST00000591118
ENST00000591266
ENST00000586939 ENSP00000467430
ENST00000587485
ENST00000590787
ENST00000590806
ENST00000593220
ENST00000593203
ENST00000585892 ENSP00000468734
ENST00000591818 ENSP00000466621
ENST00000589106 ENSP00000466914
ENST00000591701
ENST00000586130
ENST00000587830 ENSP00000466603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 116 [view]
Protein-Protein 116 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008017 microtubule binding
GO:0019899 enzyme binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006184 GTP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0008219 cell death
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623 receptor internalization
GO:0033572 transferrin transport
GO:0043065 positive regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046209 nitric oxide metabolic process
GO:0048489 synaptic vesicle transport
GO:0050999 regulation of nitric-oxide synthase activity
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030496 midbody
GO:0030666 endocytic vesicle membrane
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
BCR pathway
IL5 pathway
Prolactin pathway
REACTOME
MHC class II antigen presentation pathway
Developmental Biology pathway
Signalling by NGF pathway
Gap junction degradation pathway
trans-Golgi Network Vesicle Budding pathway
eNOS activation and regulation pathway
Formation of annular gap junctions pathway
Innate Immune System pathway
Metabolism of nitric oxide pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
Signal Transduction pathway
Gap junction trafficking pathway
Recycling pathway of L1 pathway
Adaptive Immune System pathway
Clathrin derived vesicle budding pathway
Immune System pathway
NOSTRIN mediated eNOS trafficking pathway
NGF signalling via TRKA from the plasma membrane pathway
Golgi Associated Vesicle Biogenesis pathway
Retrograde neurotrophin signalling pathway
L1CAM interactions pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Lysosome Vesicle Biogenesis pathway
Metabolism pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
Fc gamma R-mediated phagocytosis pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Arf6 trafficking events
PDGFR-beta signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.211463 Hs.661689 Hs.671264
RefSeq NM_001005360 NM_001005361 NM_001005362 NM_001190716 NM_004945
HUGO
OMIM
CCDS CCDS32907 CCDS32908 CCDS45968 CCDS45969 CCDS59351
HPRD 03852
IMGT
EMBL
GenPept
RNA Seq Atlas