Homo sapiens Gene: AURKB
Summary
InnateDB Gene IDBG-28278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AURKB
Gene Name aurora kinase B
Synonyms AIK2; AIM-1; AIM1; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK12; STK5;
Species Homo sapiens
Ensembl Gene ENSG00000178999
Encoded Proteins
aurora kinase B
aurora kinase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8204733-8210600
Strand Reverse strand
Band p13.1
Transcripts
ENST00000316199 ENSP00000313950
ENST00000534871 ENSP00000443869
ENST00000584972 ENSP00000462858
ENST00000585124 ENSP00000463999
ENST00000580998 ENSP00000461981
ENST00000583915 ENSP00000462027
ENST00000582368 ENSP00000464031
ENST00000584561
ENST00000580390
ENST00000578753
ENST00000583124
ENST00000578549 ENSP00000462207
ENST00000581511 ENSP00000462930
ENST00000577833 ENSP00000463636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 203 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 203 [view]
Protein-Protein 195 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035174 histone serine kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0002903 negative regulation of B cell apoptotic process
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0007568 aging
GO:0008283 cell proliferation
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0009838 abscission
GO:0016570 histone modification
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031565 cytokinesis checkpoint
GO:0031577 spindle checkpoint
GO:0032091 negative regulation of protein binding
GO:0032466 negative regulation of cytokinesis
GO:0032467 positive regulation of cytokinesis
GO:0034501 protein localization to kinetochore
GO:0034644 cellular response to UV
GO:0036089 cleavage furrow formation
GO:0043146 spindle stabilization
GO:0043988 histone H3-S28 phosphorylation
GO:0046777 protein autophosphorylation
GO:0051256 spindle midzone assembly involved in mitosis
GO:0051983 regulation of chromosome segregation
Cellular Component
GO:0000779 condensed chromosome, centromeric region
GO:0000780 condensed nuclear chromosome, centromeric region
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
GO:0010369 chromocenter
GO:0030496 midbody
GO:0032133 chromosome passenger complex
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora C signaling
Aurora A signaling
Aurora B signaling
FOXM1 transcription factor network
Signaling by Aurora kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001256834 NM_001284526 NM_004217 XM_005256854
HUGO
OMIM
CCDS CCDS11134 CCDS58514 CCDS67162
HPRD 05397
IMGT
EMBL
GenPept
RNA Seq Atlas