Homo sapiens Gene: CARM1
Summary
InnateDB Gene IDBG-28472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARM1
Gene Name coactivator-associated arginine methyltransferase 1
Synonyms PRMT4;
Species Homo sapiens
Ensembl Gene ENSG00000142453
Encoded Proteins
coactivator-associated arginine methyltransferase 1
coactivator-associated arginine methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation (Frankel et al., 2002 [PubMed 11724789]).[supplied by OMIM, Mar 2008]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10871513-10923070
Strand Forward strand
Band p13.2
Transcripts
ENST00000327064 ENSP00000325690
ENST00000344150 ENSP00000340934
ENST00000588947 ENSP00000465417
ENST00000586221 ENSP00000467746
ENST00000590699 ENSP00000467420
ENST00000590039 ENSP00000464852
ENST00000589693 ENSP00000468319
ENST00000592516
ENST00000586298 ENSP00000467761
ENST00000586508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 102 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0035642 histone methyltransferase activity (H3-R17 specific)
GO:0042054 histone methyltransferase activity
GO:0042803 protein homodimerization activity
GO:0044212 transcription regulatory region DNA binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0009405 pathogenesis
GO:0016032 viral process
GO:0016571 histone methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034969 histone arginine methylation
GO:0034970 histone H3-R2 methylation
GO:0034971 histone H3-R17 methylation
GO:0035246 peptidyl-arginine N-methylation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045600 positive regulation of fat cell differentiation
GO:0051591 response to cAMP
GO:0060350 endochondral bone morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Circadian Clock pathway
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
REV-ERBA represses gene expression pathway
Mitochondrial biogenesis pathway
PPARA activates gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Generic Transcription Pathway pathway
RORA activates circadian gene expression pathway
Orphan transporters pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Transcriptional activation of mitochondrial biogenesis pathway
Chromatin organization pathway
RMTs methylate histone arginines pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Chromatin modifying enzymes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
Role of erbb2 in signal transduction and oncology [Biocarta view]
Control of gene expression by vitamin d receptor [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
Carm1 and regulation of the estrogen receptor [Biocarta view]
PID NCI
Coregulation of Androgen receptor activity
Direct p53 effectors
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL K7EQB9
UniProt Splice Variant
Entrez Gene 10498
UniGene Hs.323213 Hs.734431
RefSeq NM_199141 XM_005259708
HUGO HGNC:23393
OMIM 603934
CCDS CCDS12250
HPRD 09158
IMGT
EMBL AC007565 AC011442
GenPept
RNA Seq Atlas 10498