Version 5.4
Homo sapiens Gene: ARPC1B
Summary
InnateDB Gene IDBG-28961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC1B
Gene Name actin related protein 2/3 complex, subunit 1B, 41kDa
Synonyms ARC41; p40-ARC; p41-ARC
Species Homo sapiens
Ensembl Gene ENSG00000130429
Encoded Proteins
IDBP-28963
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382763
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382765
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382774
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382777
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382780
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382782
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382783
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382784
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382786
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382788
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382791
actin related protein 2/3 complex, subunit 1B, 41kDa
IDBP-382792
actin related protein 2/3 complex, subunit 1B, 41kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99374249-99394801
Strand Forward strand
Band q22.1
Transcripts
ENST00000252725 ENSP00000252725
ENST00000443222 ENSP00000413173
ENST00000414376 ENSP00000398620
ENST00000455009 ENSP00000410238
ENST00000418347 ENSP00000413067
ENST00000451682 ENSP00000389631
ENST00000431816 ENSP00000398110
ENST00000427217 ENSP00000403211
ENST00000458033 ENSP00000388802
ENST00000417330 ENSP00000403324
ENST00000429246 ENSP00000408758
ENST00000432343 ENSP00000399955
ENST00000445924 ENSP00000408508
ENST00000484600
ENST00000484375
ENST00000474880
ENST00000493403
ENST00000468337
ENST00000481997
ENST00000491294
ENST00000463078
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0030833 regulation of actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029622
View Gene Order
ENSBTAG00000046248
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL C9JM51
UniProt Splice Variant
Entrez Gene 10095
UniGene
RefSeq NM_005720 XM_006715825 XM_006715826
HUGO HGNC:704
OMIM 604223
CCDS CCDS5661
HPRD 10366
IMGT
EMBL AC004922
GenPept
RNA Seq Atlas 10095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca