Version 5.4
Homo sapiens Gene: HDAC7
Summary
InnateDB Gene IDBG-29060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC7
Gene Name histone deacetylase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000061273
Encoded Proteins
IDBP-29062
histone deacetylase 7
IDBP-29066
histone deacetylase 7
IDBP-29068
histone deacetylase 7
IDBP-373568
histone deacetylase 7
IDBP-373571
histone deacetylase 7
IDBP-373573
histone deacetylase 7
IDBP-373574
histone deacetylase 7
IDBP-373576
histone deacetylase 7
IDBP-373577
histone deacetylase 7
IDBP-373579
histone deacetylase 7
IDBP-373580
histone deacetylase 7
IDBP-373581
histone deacetylase 7
IDBP-373586
histone deacetylase 7
IDBP-373589
histone deacetylase 7
IDBP-373591
histone deacetylase 7
IDBP-373592
histone deacetylase 7
IDBP-592362
histone deacetylase 7
IDBP-813278
histone deacetylase 7
IDBP-589237
histone deacetylase 7
IDBP-591865
histone deacetylase 7
IDBP-584598
histone deacetylase 7
IDBP-597823
histone deacetylase 7
IDBP-583572
histone deacetylase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:47782722-47833132
Strand Reverse strand
Band q13.11
Transcripts
ENST00000354334 ENSP00000351326
ENST00000080059 ENSP00000080059
ENST00000380610 ENSP00000369984
ENST00000430670 ENSP00000396159
ENST00000422254 ENSP00000410068
ENST00000440293 ENSP00000411058
ENST00000447463 ENSP00000389501
ENST00000434070 ENSP00000388561
ENST00000421231 ENSP00000412155
ENST00000425451 ENSP00000401872
ENST00000427332 ENSP00000404394
ENST00000450805 ENSP00000397236
ENST00000417902 ENSP00000400811
ENST00000433685 ENSP00000403149
ENST00000417107 ENSP00000387792
ENST00000445237 ENSP00000390415
ENST00000470668
ENST00000459625
ENST00000477203 ENSP00000449171
ENST00000471235
ENST00000488927 ENSP00000482003
ENST00000477937
ENST00000491464
ENST00000463732
ENST00000485796 ENSP00000448448
ENST00000548938 ENSP00000448305
ENST00000548080 ENSP00000446538
ENST00000549883
ENST00000552960 ENSP00000448532
ENST00000547259 ENSP00000447191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 149 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 62 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033613 activating transcription factor binding
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0071889 14-3-3 protein binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0006351 transcription, DNA-templated
GO:0007043 cell-cell junction assembly
GO:0007219 Notch signaling pathway
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0032703 negative regulation of interleukin-2 production
GO:0045668 negative regulation of osteoblast differentiation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022475
View Gene Order
ENSBTAG00000026819
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
hif1_tfpathway
HIF-1-alpha transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q8WUI4
TrEMBL C9J102 C9JAH2 C9JBC2 C9JEB6 C9JF80 C9JGF5 C9JH46 C9JKN3 C9JNI4 C9JS90 C9JVZ1 C9JZ79 F8VWY3 H0YI41 J3KPH8
UniProt Splice Variant
Entrez Gene 51564
UniGene Hs.709475
RefSeq NM_001098416 NM_015401 XM_005268968 XM_006719454 XM_006719456
HUGO HGNC:14067
OMIM 606542
CCDS CCDS41776 CCDS8756
HPRD
IMGT
EMBL AC004466 AF239243 AK001032 AK001190 AK024469 AK027781 AK122588 AK128383 AK299292 AK301545 AK303481 AL117455 AY302468 AY321367 BC006453 BC020505 BC064840 BT009771 CH471111
GenPept AAF63491 AAH06453 AAH20505 AAH64840 AAP84704 AAP88773 AAQ18232 BAA91474 BAA91545 BAB15759 BAB55363 BAC56929 BAG54670 BAG61307 BAG63042 BAG64517 CAB55935 EAW57957
RNA Seq Atlas 51564

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca