Homo sapiens Gene: HDAC7
Summary
InnateDB Gene IDBG-29060.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC7
Gene Name histone deacetylase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000061273
Encoded Proteins
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
histone deacetylase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:47782722-47833132
Strand Reverse strand
Band q13.11
Transcripts
ENST00000354334 ENSP00000351326
ENST00000080059 ENSP00000080059
ENST00000380610 ENSP00000369984
ENST00000430670 ENSP00000396159
ENST00000422254 ENSP00000410068
ENST00000440293 ENSP00000411058
ENST00000447463 ENSP00000389501
ENST00000434070 ENSP00000388561
ENST00000421231 ENSP00000412155
ENST00000425451 ENSP00000401872
ENST00000427332 ENSP00000404394
ENST00000450805 ENSP00000397236
ENST00000417902 ENSP00000400811
ENST00000433685 ENSP00000403149
ENST00000417107 ENSP00000387792
ENST00000445237 ENSP00000390415
ENST00000470668
ENST00000459625
ENST00000477203 ENSP00000449171
ENST00000471235
ENST00000488927 ENSP00000482003
ENST00000477937
ENST00000491464
ENST00000463732
ENST00000485796 ENSP00000448448
ENST00000548938 ENSP00000448305
ENST00000548080 ENSP00000446538
ENST00000549883
ENST00000552960 ENSP00000448532
ENST00000547259 ENSP00000447191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 149 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 62 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033613 activating transcription factor binding
GO:0046872 metal ion binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491 repressing transcription factor binding
GO:0071889 14-3-3 protein binding
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0006351 transcription, DNA-templated
GO:0007043 cell-cell junction assembly
GO:0007219 Notch signaling pathway
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0032703 negative regulation of interleukin-2 production
GO:0045668 negative regulation of osteoblast differentiation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TCR pathway
BCR pathway
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
INOH
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Signaling events mediated by HDAC Class II
HIF-1-alpha transcription factor network
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51564
UniGene Hs.709475
RefSeq NM_001098416 NM_015401 XM_006719456 XM_005268968 XM_006719454
HUGO HGNC:14067
OMIM 606542
CCDS CCDS41776 CCDS8756
HPRD 09133
IMGT
EMBL
GenPept
RNA Seq Atlas 51564