Version 5.4
Homo sapiens Gene: PRMT5
Summary
InnateDB Gene IDBG-2920.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT5
Gene Name protein arginine methyltransferase 5
Synonyms HRMT1L5; IBP72; JBP1; SKB1; SKB1Hs
Species Homo sapiens
Ensembl Gene ENSG00000100462
Encoded Proteins
IDBP-2922
protein arginine methyltransferase 5
IDBP-2924
protein arginine methyltransferase 5
IDBP-235305
protein arginine methyltransferase 5
IDBP-235307
protein arginine methyltransferase 5
IDBP-361767
protein arginine methyltransferase 5
IDBP-361772
protein arginine methyltransferase 5
IDBP-590933
protein arginine methyltransferase 5
IDBP-601417
protein arginine methyltransferase 5
IDBP-599897
protein arginine methyltransferase 5
IDBP-600677
protein arginine methyltransferase 5
IDBP-598920
protein arginine methyltransferase 5
IDBP-592437
protein arginine methyltransferase 5
IDBP-586622
protein arginine methyltransferase 5
IDBP-589310
protein arginine methyltransferase 5
IDBP-589034
protein arginine methyltransferase 5
IDBP-588738
protein arginine methyltransferase 5
IDBP-584932
protein arginine methyltransferase 5
IDBP-599843
protein arginine methyltransferase 5
IDBP-600346
protein arginine methyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:22920511-22929585
Strand Reverse strand
Band q11.2
Transcripts
ENST00000324366 ENSP00000319169
ENST00000216350 ENSP00000216350
ENST00000397441 ENSP00000380583
ENST00000397440 ENSP00000380582
ENST00000454731 ENSP00000387663
ENST00000421938 ENSP00000409482
ENST00000476175
ENST00000557443 ENSP00000452501
ENST00000555454 ENSP00000451245
ENST00000553915 ENSP00000451127
ENST00000553897 ENSP00000452555
ENST00000557758
ENST00000553502 ENSP00000450956
ENST00000555530 ENSP00000452409
ENST00000556043 ENSP00000452509
ENST00000553550 ENSP00000450737
ENST00000554716
ENST00000553787 ENSP00000452102
ENST00000553641
ENST00000554867 ENSP00000452218
ENST00000557415 ENSP00000450633
ENST00000556616 ENSP00000450919
ENST00000554910 ENSP00000452411
ENST00000553417
ENST00000556032
ENST00000557015
ENST00000556426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 217 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 217 [view]
Protein-Protein 211 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000387 spliceosomal snRNP assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0007088 regulation of mitosis
GO:0008283 cell proliferation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0018216 peptidyl-arginine methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032922 circadian regulation of gene expression
GO:0034660 ncRNA metabolic process
GO:0035246 peptidyl-arginine N-methylation
GO:0042118 endothelial cell activation
GO:0043985 histone H4-R3 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034709 methylosome
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023110
View Gene Order
ENSBTAG00000010890
Not yet available
Pathways
NETPATH
REACTOME
REACT_11066
snRNP Assembly pathway
REACT_11052
Metabolism of non-coding RNA pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
p53regulationpathway
p53 pathway
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL H0YJD3
UniProt Splice Variant
Entrez Gene 10419
UniGene Hs.367854
RefSeq NM_001039619 NM_001282953 NM_001282954 NM_001282955 NM_001282956 NM_006109
HUGO HGNC:10894
OMIM 604045
CCDS CCDS41922 CCDS61394 CCDS61395 CCDS61396 CCDS9579
HPRD 04955
IMGT
EMBL AL132780
GenPept
RNA Seq Atlas 10419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca