Version 5.4
Homo sapiens Gene: VPS35
Summary
InnateDB Gene IDBG-29257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS35
Gene Name vacuolar protein sorting 35 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000069329
Encoded Proteins
IDBP-29259
vacuolar protein sorting 35 homolog (S. cerevisiae)
IDBP-754270
IDBP-749390
IDBP-752289
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46656132-46689518
Strand Reverse strand
Band q11.2
Transcripts
ENST00000299138 ENSP00000299138
ENST00000568784 ENSP00000456274
ENST00000561713 ENSP00000461423
ENST00000569950
ENST00000568642
ENST00000568191
ENST00000568612 ENSP00000461469
ENST00000565228
ENST00000563884
ENST00000562420
ENST00000563984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0008219 cell death
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005829 cytosol
GO:0030904 retromer complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031696
View Gene Order
ENSBTAG00000002493
Not yet available
Pathways
NETPATH
REACTOME
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_228014
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
REACT_111102
Signal Transduction pathway
REACT_163710
WNT ligand biogenesis and trafficking pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595143 Hs.717753
RefSeq NM_018206 XM_005256045
HUGO
OMIM
CCDS CCDS10721
HPRD 06085
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca