Homo sapiens Gene: UQCRB
Summary
InnateDB Gene IDBG-29384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UQCRB
Gene Name ubiquinol-cytochrome c reductase binding protein
Synonyms MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6; UQPC;
Species Homo sapiens
Ensembl Gene ENSG00000156467
Encoded Proteins
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
ubiquinol-cytochrome c reductase binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:96225920-96235634
Strand Reverse strand
Band q22.1
Transcripts
ENST00000287022 ENSP00000287022
ENST00000517603 ENSP00000430672
ENST00000521036 ENSP00000427862
ENST00000518876
ENST00000517523 ENSP00000429787
ENST00000518406 ENSP00000430494
ENST00000521948
ENST00000523920 ENSP00000430560
ENST00000519322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006119 oxidative phosphorylation
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0005750 mitochondrial respiratory chain complex III
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Cardiac muscle contraction pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E5RHG9
UniProt Splice Variant
Entrez Gene 7381
UniGene Hs.404298 Hs.663220
RefSeq NM_001199975 NM_006294 NM_001254752 XM_006716652
HUGO HGNC:12582
OMIM 191330
CCDS CCDS6269 CCDS59107
HPRD 11770
IMGT
EMBL AP003465
GenPept
RNA Seq Atlas 102725189 7381