Version 5.4
Homo sapiens Gene: GPT2
Summary
InnateDB Gene IDBG-29426.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPT2
Gene Name glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166123
Encoded Proteins
IDBP-29428
glutamic pyruvate transaminase (alanine aminotransferase) 2
IDBP-376474
glutamic pyruvate transaminase (alanine aminotransferase) 2
IDBP-745057
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46884378-46931297
Strand Forward strand
Band q11.2
Transcripts
ENST00000340124 ENSP00000345282
ENST00000440783 ENSP00000413804
ENST00000569193
ENST00000562801
ENST00000562132 ENSP00000457475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042851 L-alanine metabolic process
GO:0042853 L-alanine catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031700
View Gene Order
ENSBTAG00000002980
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt Q8TD30
TrEMBL A0A024R6R2 B3KR40 H3BU54
UniProt Splice Variant
Entrez Gene 84706
UniGene Hs.460693
RefSeq NM_001142466 NM_133443
HUGO HGNC:18062
OMIM 138210
CCDS CCDS10725 CCDS45478
HPRD
IMGT
EMBL AC007225 AC018845 AK090957 AK094971 AY029173 BC062555 CH471092
GenPept AAH62555 AAK31794 BAC04465 BAG52252 EAW82691 EAW82692
RNA Seq Atlas 84706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca