Homo sapiens Gene: ABCC11
Summary
InnateDB Gene IDBG-29877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCC11
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121270
Encoded Proteins
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:48166910-48247568
Strand Reverse strand
Band q12.1
Transcripts
ENST00000356608 ENSP00000349017
ENST00000353782 ENSP00000311326
ENST00000394748 ENSP00000378231
ENST00000394747 ENSP00000378230
ENST00000565487
ENST00000569172
ENST00000567385
ENST00000565329
ENST00000569991 ENSP00000456268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015216 purine nucleotide transmembrane transporter activity
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0015711 organic anion transport
GO:0015865 purine nucleotide transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BRJ2
UniProt Splice Variant
Entrez Gene 85320
UniGene Hs.652267
RefSeq NM_145186 NM_033151 NM_032583
HUGO HGNC:14639
OMIM 607040
CCDS CCDS10732 CCDS10733
HPRD 06127
IMGT
EMBL AC007600 AC096996
GenPept
RNA Seq Atlas 85320