Homo sapiens Gene: STK3
Summary
InnateDB Gene IDBG-30072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK3
Gene Name serine/threonine kinase 3
Synonyms KRS1; MST2;
Species Homo sapiens
Ensembl Gene ENSG00000104375
Encoded Proteins
serine/threonine kinase 3
serine/threonine kinase 3
serine/threonine kinase 3
serine/threonine kinase 3
serine/threonine kinase 3
serine/threonine kinase 3
serine/threonine kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:98401403-98942827
Strand Reverse strand
Band q22.2
Transcripts
ENST00000419617 ENSP00000390500
ENST00000424861 ENSP00000428167
ENST00000517832
ENST00000523601 ENSP00000429744
ENST00000520440
ENST00000518582
ENST00000523159
ENST00000518165 ENSP00000428014
ENST00000518627
ENST00000522924
ENST00000521649 ENSP00000429369
ENST00000520053
ENST00000521768
ENST00000520653
ENST00000523567
ENST00000523960
ENST00000519420 ENSP00000428295
ENST00000617590 ENSP00000482260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
Experimentally validated
Total 119 [view]
Protein-Protein 118 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043539 protein serine/threonine kinase activator activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001841 neural tube formation
GO:0003157 endocardium development
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0023014 signal transduction by phosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0046621 negative regulation of organ growth
GO:0051897 positive regulation of protein kinase B signaling
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.492333 Hs.607421 Hs.609702 Hs.738869
RefSeq NM_001256312 NM_001256313 NM_006281
HUGO
OMIM
CCDS CCDS47900 CCDS59108 CCDS75774
HPRD 05433
IMGT
EMBL
GenPept
RNA Seq Atlas