Version 5.4
Homo sapiens Gene: SNCA
Summary
InnateDB Gene IDBG-30077.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCA
Gene Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms NACP; PARK1; PARK4; PD1
Species Homo sapiens
Ensembl Gene ENSG00000145335
Encoded Proteins
IDBP-30079
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-30081
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-240458
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-240460
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-240462
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-374364
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-474993
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-484596
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-478419
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-479130
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-483910
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-809260
synuclein, alpha (non A4 component of amyloid precursor)
IDBP-809266
synuclein, alpha (non A4 component of amyloid precursor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21747756
SNCA acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation.
InnateDB Annotation from Orthologs
Summary
PMID 21747756
[Mus musculus] Snca acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation. (Demonstrated in human)
Entrez Gene
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer\'s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:89724099-89838315
Strand Reverse strand
Band q22.1
Transcripts
ENST00000336904 ENSP00000338345
ENST00000345009 ENSP00000343683
ENST00000394991 ENSP00000378442
ENST00000394989 ENSP00000378440
ENST00000394986 ENSP00000378437
ENST00000420646 ENSP00000396241
ENST00000508895 ENSP00000426955
ENST00000506244 ENSP00000422238
ENST00000505199 ENSP00000421485
ENST00000502987 ENSP00000426034
ENST00000506691 ENSP00000423445
ENST00000611107 ENSP00000479604
ENST00000618500 ENSP00000484044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 384 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 384 [view]
Protein-Protein 380 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008017 microtubule binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019894 kinesin binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030544 Hsp70 protein binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043274 phospholipase binding
GO:0045502 dynein binding
GO:0047485 protein N-terminus binding
GO:0048156 tau protein binding
GO:0048487 beta-tubulin binding
GO:0050544 arachidonic acid binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001774 microglial cell activation
GO:0001921 positive regulation of receptor recycling
GO:0001933 negative regulation of protein phosphorylation
GO:0001956 positive regulation of neurotransmitter secretion
GO:0001963 synaptic transmission, dopaminergic
GO:0006631 fatty acid metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 mitochondrial membrane organization
GO:0007268 synaptic transmission
GO:0007568 aging
GO:0008344 adult locomotory behavior
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0034599 cellular response to oxidative stress
GO:0035067 negative regulation of histone acetylation
GO:0040012 regulation of locomotion
GO:0042220 response to cocaine
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043206 extracellular fibril organization
GO:0043524 negative regulation of neuron apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045087 innate immune response (InnateDB)
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0045963 negative regulation of dopamine metabolic process
GO:0046928 regulation of neurotransmitter secretion
GO:0048148 behavioral response to cocaine
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0050806 positive regulation of synaptic transmission
GO:0050808 synapse organization
GO:0050812 regulation of acyl-CoA biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 negative regulation of serotonin uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0055114 oxidation-reduction process
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060291 long-term synaptic potentiation
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0061024 membrane organization
GO:0070495 negative regulation of thrombin receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0071280 cellular response to copper ion
GO:0071872 cellular response to epinephrine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1901214 regulation of neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0008021 synaptic vesicle
GO:0015629 actin cytoskeleton
GO:0016234 inclusion body
GO:0030054 cell junction
GO:0030424 axon
GO:0030426 growth cone
GO:0030659 cytoplasmic vesicle membrane
GO:0031092 platelet alpha granule membrane
GO:0043195 terminal bouton
GO:0043205 fibril
GO:0043231 intracellular membrane-bounded organelle
GO:0043679 axon terminus
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025889
View Gene Order
ENSBTAG00000024957
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa05012
Parkinson's disease pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604559
RefSeq NM_000345 NM_001146054 NM_001146055 NM_007308
HUGO
OMIM
CCDS CCDS3634 CCDS43252
HPRD 01227
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca