Homo sapiens Gene: IQGAP1
Summary
InnateDB Gene IDBG-30204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQGAP1
Gene Name IQ motif containing GTPase activating protein 1
Synonyms HUMORFA01; p195; SAR1;
Species Homo sapiens
Ensembl Gene ENSG00000140575
Encoded Proteins
IQ motif containing GTPase activating protein 1
IQ motif containing GTPase activating protein 1
IQ motif containing GTPase activating protein 1
IQ motif containing GTPase activating protein 1
IQ motif containing GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90388218-90502243
Strand Forward strand
Band q26.1
Transcripts
ENST00000268182 ENSP00000268182
ENST00000560738 ENSP00000453181
ENST00000560418 ENSP00000452723
ENST00000559809 ENSP00000484647
ENST00000559682
ENST00000560373 ENSP00000480393
ENST00000558003
ENST00000560733
ENST00000560020
ENST00000560218
ENST00000558491
ENST00000561132
ENST00000561461
ENST00000559031
ENST00000559674
ENST00000558957
ENST00000561086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 161 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017048 Rho GTPase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0032403 protein complex binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0035305 negative regulation of dephosphorylation
GO:0043086 negative regulation of catalytic activity
GO:0043547 positive regulation of GTPase activity
GO:0044281 small molecule metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0050796 regulation of insulin secretion
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0071277 cellular response to calcium ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072015 glomerular visceral epithelial cell development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0030054 cell junction
GO:0030496 midbody
GO:0030529 ribonucleoprotein complex
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 cell leading edge
GO:0036057 slit diaphragm
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Integration of energy metabolism pathway
Cell-Cell communication pathway
Nephrin interactions pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
Metabolism pathway
KEGG
Adherens junction pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
ErbB1 downstream signaling
Nectin adhesion pathway
Integrin-linked kinase signaling
RAC1 signaling pathway
C-MYB transcription factor network
CDC42 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.430551
RefSeq NM_003870 XM_005254984
HUGO
OMIM
CCDS CCDS10362
HPRD 04541
IMGT
EMBL
GenPept
RNA Seq Atlas