InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IQGAP1

Summary

InnateDB Gene

IDBG-30204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP1

Gene Name

IQ motif containing GTPase activating protein 1

Synonyms

HUMORFA01; p195; SAR1

Species

Homo sapiens

Ensembl Gene

ENSG00000140575

Encoded Proteins

IDBP-30206

IQ motif containing GTPase activating protein 1

IDBP-587105

IQ motif containing GTPase activating protein 1

IDBP-594525

IQ motif containing GTPase activating protein 1

IDBP-813094

IQ motif containing GTPase activating protein 1

IDBP-813096

IQ motif containing GTPase activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:90388218-90502243

Strand

Forward strand

Band

q26.1

Transcripts

ENST00000268182	ENSP00000268182
ENST00000560738	ENSP00000453181
ENST00000560418	ENSP00000452723
ENST00000559809	ENSP00000484647
ENST00000559682
ENST00000560373	ENSP00000480393
ENST00000558003
ENST00000560733
ENST00000560020
ENST00000560218
ENST00000558491
ENST00000561132
ENST00000561461
ENST00000559031
ENST00000559674
ENST00000558957
ENST00000561086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	161 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017048	Rho GTPase binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006112	energy reserve metabolic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0035305	negative regulation of dephosphorylation
GO:0043086	negative regulation of catalytic activity
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0045860	positive regulation of protein kinase activity
GO:0050796	regulation of insulin secretion
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0071277	cellular response to calcium ion
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0072015	glomerular visceral epithelial cell development

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0030496	midbody
GO:0030529	ribonucleoprotein complex
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031252	cell leading edge
GO:0036057	slit diaphragm
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome