Version 5.4
Homo sapiens Gene: MYH1
Summary
InnateDB Gene IDBG-30342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH1
Gene Name myosin, heavy chain 1, skeletal muscle, adult
Synonyms HEL71; MYHa; MyHC-2x; MyHC-2X/D; MYHSA1
Species Homo sapiens
Ensembl Gene ENSG00000109061
Encoded Proteins
IDBP-30344
myosin, heavy chain 1, skeletal muscle, adult
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:10492307-10518543
Strand Reverse strand
Band p13.1
Transcripts
ENST00000226207 ENSP00000226207
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
Biological Process
GO:0006936 muscle contraction
GO:0008152 metabolic process
Cellular Component
GO:0005859 muscle myosin complex
GO:0014704 intercalated disc
GO:0016459 myosin complex
GO:0031672 A band
GO:0032982 myosin filament
GO:0036464 cytoplasmic ribonucleoprotein granule
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000056328
View Gene Order
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt P12882
TrEMBL
UniProt Splice Variant
Entrez Gene 4619
UniGene Hs.689619
RefSeq NM_005963
HUGO HGNC:7567
OMIM 160730
CCDS CCDS11155
HPRD
IMGT
EMBL AC005323 AF111785 BC114545 X03740
GenPept AAD29951 AAI14546 CAA27380
RNA Seq Atlas 4619

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca