Homo sapiens Gene: NLRP10
Summary
InnateDB Gene IDBG-30412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP10
Gene Name NLR family, pyrin domain containing 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182261
Encoded Proteins
NLR family, pyrin domain containing 10
NLR family, pyrin domain containing 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NLRP10 oligomerizes and binds to PYCARD, inhibits PYCARD mediated NF-kappaB activation and apoptosis, as well as CASP1-mediated IL1B maturation.
Entrez Gene
Summary Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:7959424-7965426
Strand Reverse strand
Band p15.4
Transcripts
ENST00000328600 ENSP00000327763
ENST00000526590 ENSP00000436255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0035397 helper T cell enhancement of adaptive immune response
GO:0036336 dendritic cell migration
GO:0045087 innate immune response (InnateDB)
GO:0050829 defense response to Gram-negative bacterium
GO:0050832 defense response to fungus
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component
GO:0005737 cytoplasm
GO:0019897 extrinsic component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q86W26
TrEMBL E9PPY0
UniProt Splice Variant
Entrez Gene 338322
UniGene Hs.449636 Hs.694552
RefSeq NM_176821
HUGO HGNC:21464
OMIM 609662
CCDS CCDS7784
HPRD 14802
IMGT
EMBL AC044810 AY154465 AY489192 BC104957 BK001110
GenPept AAI04958 AAO18161 AAS67384 DAA01243
RNA Seq Atlas 338322