InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS18

Summary

InnateDB Gene

IDBG-304152.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS18

Gene Name

ribosomal protein S18

Synonyms

D6S218E; HKE3; KE-3; KE3; S18

Species

Homo sapiens

Ensembl Gene

ENSG00000231500

Encoded Proteins

IDBP-375444

ribosomal protein S18

IDBP-601480

ribosomal protein S18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:33272010-33276510

Strand

Forward strand

Band

p21.32

Transcripts

ENST00000439602	ENSP00000393241
ENST00000474973	ENSP00000434837
ENST00000474626
ENST00000476222
ENST00000496813
ENST00000490191
ENST00000472218
ENST00000479802

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	104 [view]
Protein-Protein	103 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042254	ribosome biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005581	collagen trimer
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome