InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC26A6

Summary

InnateDB Gene

IDBG-304554.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A6

Gene Name

solute carrier family 26, member 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000225697

Encoded Proteins

IDBP-33332

solute carrier family 26, member 6

IDBP-33334

solute carrier family 26, member 6

IDBP-33336

solute carrier family 26, member 6

IDBP-33340

solute carrier family 26, member 6

IDBP-239269

solute carrier family 26, member 6

IDBP-376302

solute carrier family 26, member 6

IDBP-376304

solute carrier family 26, member 6

IDBP-376317

solute carrier family 26, member 6

IDBP-376322

solute carrier family 26, member 6

IDBP-376323

solute carrier family 26, member 6

IDBP-376325

solute carrier family 26, member 6

IDBP-376328

solute carrier family 26, member 6

IDBP-376330

solute carrier family 26, member 6

IDBP-812343

solute carrier family 26 (anion exchanger), member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:48625723-48635493

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000383733	ENSP00000373239
ENST00000358747	ENSP00000351597
ENST00000337000	ENSP00000337648
ENST00000307364	ENSP00000307089
ENST00000395550	ENSP00000378920
ENST00000420764	ENSP00000404684
ENST00000455886	ENSP00000401066
ENST00000421649	ENSP00000389922
ENST00000444531	ENSP00000404607
ENST00000414944	ENSP00000388721
ENST00000431213	ENSP00000387532
ENST00000431739	ENSP00000401813
ENST00000426599	ENSP00000405872
ENST00000489483
ENST00000480524
ENST00000466257
ENST00000462009
ENST00000469693
ENST00000496469
ENST00000485361
ENST00000494717
ENST00000482282
ENST00000614797	ENSP00000483669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity
GO:0015499	formate transmembrane transporter activity
GO:0015562	efflux transmembrane transporter activity
GO:0015659	formate uptake transmembrane transporter activity
GO:0015660	formate efflux transmembrane transporter activity
GO:0019531	oxalate transmembrane transporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0015724	formate transport
GO:0015797	mannitol transport
GO:0019532	oxalate transport
GO:0030321	transepithelial chloride transport
GO:0038166	angiotensin-activated signaling pathway
GO:0042045	epithelial fluid transport
GO:0046724	oxalic acid secretion
GO:0048240	sperm capacitation
GO:0050892	intestinal absorption
GO:0051453	regulation of intracellular pH
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0070528	protein kinase C signaling
GO:0070633	transepithelial transport
GO:0071320	cellular response to cAMP
GO:0071332	cellular response to fructose stimulus
GO:0071346	cellular response to interferon-gamma
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport
GO:2001150	positive regulation of dipeptide transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031526	brush border membrane
GO:0031988	membrane-bounded vesicle
GO:0034707	chloride channel complex
GO:0097225	sperm midpiece

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023259

View Gene Order

ENSBTAG00000038381

Not yet available

Pathways

NETPATH

REACTOME

REACT_19357

Multifunctional anion exchangers pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H7BZ36

UniProt Splice Variant

Entrez Gene

65010

UniGene

Hs.631925

RefSeq

NM_001040454 NM_001281732 NM_001281733 NM_022911 NM_134263 NM_134426

HUGO

HGNC:14472

OMIM

610068

CCDS

CCDS43087 CCDS46824 CCDS46825 CCDS46826 CCDS63627 CCDS63628

HPRD

10235

IMGT

EMBL

AC121252

GenPept

RNA Seq Atlas

102465495 65010