Homo sapiens Gene: SLC26A6
Summary
InnateDB Gene IDBG-304554.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A6
Gene Name solute carrier family 26, member 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000225697
Encoded Proteins
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26, member 6
solute carrier family 26 (anion exchanger), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48625723-48635493
Strand Reverse strand
Band p21.31
Transcripts
ENST00000383733 ENSP00000373239
ENST00000358747 ENSP00000351597
ENST00000337000 ENSP00000337648
ENST00000307364 ENSP00000307089
ENST00000395550 ENSP00000378920
ENST00000420764 ENSP00000404684
ENST00000455886 ENSP00000401066
ENST00000421649 ENSP00000389922
ENST00000444531 ENSP00000404607
ENST00000414944 ENSP00000388721
ENST00000431213 ENSP00000387532
ENST00000431739 ENSP00000401813
ENST00000426599 ENSP00000405872
ENST00000489483
ENST00000480524
ENST00000466257
ENST00000462009
ENST00000469693
ENST00000496469
ENST00000485361
ENST00000494717
ENST00000482282
ENST00000614797 ENSP00000483669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0015499 formate transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015659 formate uptake transmembrane transporter activity
GO:0015660 formate efflux transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0030165 PDZ domain binding
Biological Process
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0015724 formate transport
GO:0015797 mannitol transport
GO:0019532 oxalate transport
GO:0030321 transepithelial chloride transport
GO:0038166 angiotensin-activated signaling pathway
GO:0042045 epithelial fluid transport
GO:0046724 oxalic acid secretion
GO:0048240 sperm capacitation
GO:0050892 intestinal absorption
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0070528 protein kinase C signaling
GO:0070633 transepithelial transport
GO:0071320 cellular response to cAMP
GO:0071332 cellular response to fructose stimulus
GO:0071346 cellular response to interferon-gamma
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
GO:2001150 positive regulation of dipeptide transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031526 brush border membrane
GO:0031988 membrane-bounded vesicle
GO:0034707 chloride channel complex
GO:0097225 sperm midpiece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Multifunctional anion exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H7C291
UniProt Splice Variant
Entrez Gene 65010
UniGene Hs.631925
RefSeq NM_134426 NM_134263 NM_022911 NM_001281733 NM_001281732 NM_001040454
HUGO HGNC:14472
OMIM 610068
CCDS CCDS46824 CCDS46825 CCDS43087 CCDS63627 CCDS63628 CCDS46826
HPRD 10235
IMGT
EMBL AC121252
GenPept
RNA Seq Atlas 102465495 65010