Homo sapiens Gene: FES
Summary
InnateDB Gene IDBG-30488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FES
Gene Name feline sarcoma oncogene
Synonyms FPS;
Species Homo sapiens
Ensembl Gene ENSG00000182511
Encoded Proteins
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
feline sarcoma oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90883695-90895776
Strand Forward strand
Band q26.1
Transcripts
ENST00000328850 ENSP00000331504
ENST00000394302 ENSP00000377839
ENST00000394300 ENSP00000377837
ENST00000416779 ENSP00000410477
ENST00000414248 ENSP00000414629
ENST00000452243 ENSP00000392696
ENST00000443697 ENSP00000395425
ENST00000444422 ENSP00000400868
ENST00000448367
ENST00000470152 ENSP00000454146
ENST00000481665
ENST00000464684 ENSP00000435811
ENST00000497945
ENST00000494259
ENST00000496379
ENST00000462476
ENST00000559355 ENSP00000454089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0034987 immunoglobulin receptor binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0010976 positive regulation of neuron projection development
GO:0016192 vesicle-mediated transport
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030155 regulation of cell adhesion
GO:0031116 positive regulation of microtubule polymerization
GO:0042127 regulation of cell proliferation
GO:0043304 regulation of mast cell degranulation
GO:0045595 regulation of cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0046777 protein autophosphorylation
GO:0060627 regulation of vesicle-mediated transport
GO:2000145 regulation of cell motility
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
IL3 pathway
IL4 pathway
IL6 pathway
TSLP pathway
IL11 pathway
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
Signaling by SCF-KIT pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
Signal Transduction pathway
Sema3A PAK dependent Axon repulsion pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Angiopoietin receptor Tie2-mediated signaling
IL4-mediated signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Cross-References
SwissProt P07332
TrEMBL A0A024RC92 C9J3W6 E7EMJ7 E7ENM8 E9PGC7 E9PIJ7 H0YNN8 H0YNT6 Q4JFK7
UniProt Splice Variant
Entrez Gene 2242
UniGene Hs.7636
RefSeq NM_001143783 NM_001143784 NM_001143785 NM_002005 XM_005254877 XM_005254880 XM_005254881 XM_005254882
HUGO HGNC:3657
OMIM 190030
CCDS CCDS10365 CCDS45349 CCDS45350 CCDS45351
HPRD
IMGT
EMBL AC124248 AK300595 AK312545 AY513654 AY513656 AY513657 BC035357 CH471101 M14589 X06292 X52192
GenPept AAA53105 AAH35357 AAS82866 AAS82868 AAS82869 BAG35443 BAG62292 CAA29619 CAA36438 EAX02114 EAX02115 EAX02116
RNA Seq Atlas 2242