Version 5.4
Homo sapiens Gene: COPS6
Summary
InnateDB Gene IDBG-30497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS6
Gene Name COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Synonyms CSN6; MOV34-34KD
Species Homo sapiens
Ensembl Gene ENSG00000168090
Encoded Proteins
IDBP-30499
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
IDBP-383125
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
IDBP-383126
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
IDBP-383129
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100088954-100092200
Strand Forward strand
Band q22.1
Transcripts
ENST00000303904 ENSP00000304102
ENST00000419210 ENSP00000388865
ENST00000418625 ENSP00000400617
ENST00000426712 ENSP00000413702
ENST00000465027
ENST00000472107
ENST00000468499
ENST00000496358
ENST00000474823
ENST00000483891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 338 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 338 [view]
Protein-Protein 338 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019494
View Gene Order
ENSBTAG00000002871
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006833
HUGO
OMIM
CCDS CCDS5682
HPRD 16735
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca