Homo sapiens Gene: COPS6
Summary
InnateDB Gene IDBG-30497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS6
Gene Name COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Synonyms CSN6; MOV34-34KD;
Species Homo sapiens
Ensembl Gene ENSG00000168090
Encoded Proteins
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100088954-100092200
Strand Forward strand
Band q22.1
Transcripts
ENST00000303904 ENSP00000304102
ENST00000419210 ENSP00000388865
ENST00000418625 ENSP00000400617
ENST00000426712 ENSP00000413702
ENST00000465027
ENST00000472107
ENST00000468499
ENST00000496358
ENST00000474823
ENST00000483891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 338 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 338 [view]
Protein-Protein 338 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
GO:0016032 viral process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_006833
HUGO
OMIM
CCDS CCDS5682
HPRD 16735
IMGT
EMBL
GenPept
RNA Seq Atlas