Version 5.4
Homo sapiens Gene: PRC1
Summary
InnateDB Gene IDBG-30703.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRC1
Gene Name protein regulator of cytokinesis 1
Synonyms ASE1
Species Homo sapiens
Ensembl Gene ENSG00000198901
Encoded Proteins
IDBP-30707
protein regulator of cytokinesis 1
IDBP-241964
protein regulator of cytokinesis 1
IDBP-380659
protein regulator of cytokinesis 1
IDBP-745096
IDBP-601719
protein regulator of cytokinesis 1
IDBP-588906
protein regulator of cytokinesis 1
IDBP-585064
protein regulator of cytokinesis 1
IDBP-592804
protein regulator of cytokinesis 1
IDBP-585256
protein regulator of cytokinesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:90966038-90995629
Strand Reverse strand
Band q26.1
Transcripts
ENST00000361188 ENSP00000354679
ENST00000394249 ENSP00000377793
ENST00000417173
ENST00000442656 ENSP00000409549
ENST00000556972 ENSP00000456737
ENST00000555455 ENSP00000451344
ENST00000560423 ENSP00000453977
ENST00000559828 ENSP00000453063
ENST00000559326
ENST00000560914
ENST00000556982
ENST00000553494
ENST00000557763
ENST00000560605
ENST00000557905 ENSP00000453455
ENST00000555791
ENST00000555745
ENST00000559811 ENSP00000453117
ENST00000556129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 27 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
Biological Process
GO:0000022 mitotic spindle elongation
GO:0000226 microtubule cytoskeleton organization
GO:0000910 cytokinesis
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038943
View Gene Order
ENSBTAG00000018643
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.366401 Hs.641727
RefSeq NM_001267580 NM_003981 NM_199413
HUGO
OMIM
CCDS CCDS32334 CCDS45352 CCDS45353
HPRD 17899
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca