Homo sapiens Gene: YWHAZ
Summary
InnateDB Gene IDBG-30919.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAZ
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms 14-3-3-zeta; HEL-S-3; HEL4; KCIP-1; YWHAD;
Species Homo sapiens
Ensembl Gene ENSG00000164924
Encoded Proteins
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5\' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:100916525-100953388
Strand Reverse strand
Band q22.3
Transcripts
ENST00000353245 ENSP00000309503
ENST00000395958 ENSP00000379288
ENST00000395957 ENSP00000379287
ENST00000395956 ENSP00000379286
ENST00000395953 ENSP00000379283
ENST00000395951 ENSP00000379281
ENST00000395948 ENSP00000379278
ENST00000457309 ENSP00000398599
ENST00000419477 ENSP00000395114
ENST00000418997 ENSP00000416551
ENST00000437293 ENSP00000394880
ENST00000523848 ENSP00000428860
ENST00000522542 ENSP00000430072
ENST00000521309 ENSP00000429623
ENST00000522819 ENSP00000428775
ENST00000521607 ENSP00000430058
ENST00000480304
ENST00000518736
ENST00000517727
ENST00000521328 ENSP00000429041
ENST00000523131 ENSP00000428381
ENST00000523938 ENSP00000430219
ENST00000492736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 769 experimentally validated interaction(s) in this database.
They are also associated with 155 interaction(s) predicted by orthology.
Experimentally validated
Total 769 [view]
Protein-Protein 767 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 155 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016301 kinase activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002553 histamine secretion by mast cell
GO:0006605 protein targeting
GO:0006626 protein targeting to mitochondrion
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0010467 gene expression
GO:0010941 regulation of cell death
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016310 phosphorylation
GO:0030168 platelet activation
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0061024 membrane organization
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0030659 cytoplasmic vesicle membrane
GO:0031252 cell leading edge
GO:0042470 melanosome
GO:0042629 mast cell granule
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
TNFalpha pathway
TCR pathway
IL3 pathway
IL5 pathway
Prolactin pathway
REACTOME
Rap1 signalling pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
GP1b-IX-V activation signalling pathway
Signaling by Wnt pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Platelet activation, signaling and aggregation pathway
deactivation of the beta-catenin transactivating complex pathway
Apoptosis pathway
Signal Transduction pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
Translocation of GLUT4 to the plasma membrane pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Intrinsic Pathway for Apoptosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Gene Expression pathway
KSRP destabilizes mRNA pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Pathogenic Escherichia coli infection pathway
INOH
Fas signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
ErbB1 downstream signaling
IGF1 pathway
IL3-mediated signaling events
Alpha4 beta1 integrin signaling events
GMCSF-mediated signaling events
ATR signaling pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt P63104
TrEMBL B0AZS6 B7Z2E6 D0PNI1 E5RGE1 E5RIR4 E7ESK7 E7EVZ2 E9PD24 H0YB80 Q2F831 Q6LD62
UniProt Splice Variant
Entrez Gene 7534
UniGene Hs.492407 Hs.564021 Hs.592862 Hs.593532
RefSeq NM_003406 NM_001135701 NM_001135700 NM_001135702 NM_145690 NM_001135699 XM_005251063 XM_005251062 XM_005251061 XM_005251060
HUGO HGNC:12855
OMIM 601288
CCDS CCDS6290
HPRD 03183
IMGT
EMBL AC018781 AC027373 AK289945 AK294647 AK296902 AK315867 BC003623 BC051814 BC063824 BC068456 BC072426 BC073141 BC083508 BC099904 BC101483 BC108281 BC111951 CH471060 DQ185048 EF094937 EU794582 EU794583 M86400 S79449 U28964
GenPept AAA36446 AAC52052 AAD14300 AAH03623 AAH51814 AAH63824 AAH68456 AAH72426 AAH73141 AAH83508 AAH99904 AAI01484 AAI08282 AAI11952 ABD14427 ABO15003 ACJ13636 ACJ13637 BAF82634 BAF98758 BAH11832 BAH12451 EAW91823 EAW91824 EAW91825 EAW91826 EAW91827 EAW91828 EAW91829
RNA Seq Atlas 7534