InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRDX2

Summary

InnateDB Gene

IDBG-31024.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDX2

Gene Name

peroxiredoxin 2

Synonyms

HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA

Species

Homo sapiens

Ensembl Gene

ENSG00000167815

Encoded Proteins

IDBP-31026

peroxiredoxin 2

IDBP-31028

peroxiredoxin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:12796820-12801859

Strand

Reverse strand

Band

p13.13

Transcripts

ENST00000301522	ENSP00000301522
ENST00000334482	ENSP00000334063
ENST00000466174
ENST00000498785
ENST00000478908
ENST00000477555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	58 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008379	thioredoxin peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0006979	response to oxidative stress
GO:0019430	removal of superoxide radicals
GO:0034599	cellular response to oxidative stress
GO:0042744	hydrogen peroxide catabolic process
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005161

View Gene Order

ENSBTAG00000012062

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P32119

TrEMBL

A6NIW5 V9HW12

UniProt Splice Variant

Entrez Gene

7001

UniGene

RefSeq

NM_005809

HUGO

HGNC:9353

OMIM

600538

CCDS

CCDS12281

HPRD

IMGT

EMBL

AC018761 AK289485 BC000452 BC003022 BC039428 CH471106 CR450356 CR541789 DQ231563 EU668325 L19185 X82321 Z22548

GenPept

AAA50465 AAH00452 AAH03022 AAH39428 ABB02182 ACF94478 BAF82174 CAA57764 CAA80269 CAG29352 CAG46588 EAW84308 EAW84309 EAW84311

RNA Seq Atlas

7001