InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RRM2B

Summary

InnateDB Gene

IDBG-31119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM2B

Gene Name

ribonucleotide reductase M2 B (TP53 inducible)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000048392

Encoded Proteins

IDBP-31121

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-238594

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-475649

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-477452

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-481799

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-476259

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-477400

ribonucleotide reductase M2 B (TP53 inducible)

IDBP-811869

ribonucleotide reductase M2 B (TP53 inducible)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:102204502-102239118

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000251810	ENSP00000251810
ENST00000395912	ENSP00000379248
ENST00000395910
ENST00000522368	ENSP00000428115
ENST00000519962	ENSP00000429140
ENST00000519317	ENSP00000430641
ENST00000522394	ENSP00000429578
ENST00000519125
ENST00000523957	ENSP00000427830
ENST00000517517
ENST00000621845	ENSP00000484318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0046872	metal ion binding

Biological Process

GO:0001822	kidney development
GO:0003014	renal system process
GO:0006264	mitochondrial DNA replication
GO:0006281	DNA repair
GO:0006979	response to oxidative stress
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009200	deoxyribonucleoside triphosphate metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022292

View Gene Order

ENSBTAG00000021208

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

hsa00480

Glutathione metabolism pathway

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.512592 Hs.595724 Hs.609797

RefSeq

NM_001172477 NM_001172478 NM_015713

HUGO

OMIM

CCDS

CCDS34932 CCDS55267

HPRD

05276

IMGT

EMBL

GenPept

RNA Seq Atlas