Homo sapiens Gene: RRM2B
Summary
InnateDB Gene IDBG-31119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RRM2B
Gene Name ribonucleotide reductase M2 B (TP53 inducible)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000048392
Encoded Proteins
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
ribonucleotide reductase M2 B (TP53 inducible)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:102204502-102239118
Strand Reverse strand
Band q22.3
Transcripts
ENST00000251810 ENSP00000251810
ENST00000395912 ENSP00000379248
ENST00000395910
ENST00000522368 ENSP00000428115
ENST00000519962 ENSP00000429140
ENST00000519317 ENSP00000430641
ENST00000522394 ENSP00000429578
ENST00000519125
ENST00000523957 ENSP00000427830
ENST00000517517
ENST00000621845 ENSP00000484318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0003014 renal system process
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006979 response to oxidative stress
GO:0009186 deoxyribonucleoside diphosphate metabolic process
GO:0009200 deoxyribonucleoside triphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
Glutathione metabolism pathway
p53 signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Cross-References
SwissProt Q7LG56
TrEMBL
UniProt Splice Variant
Entrez Gene 50484
UniGene Hs.512592 Hs.595724 Hs.609797
RefSeq NM_001172477 NM_015713 NM_001172478
HUGO HGNC:17296
OMIM 604712
CCDS CCDS34932 CCDS55267
HPRD 05276
IMGT
EMBL AB036063 AB036532 AB163437 AB163438 AB166669 AB166670 AB166671 AK001965 AK304354 AL137348 AP001328 AP002907 BC042468 BC108261 BC117496 BC130628 CH471060 DC308409 DQ027001
GenPept AAH42468 AAI08262 AAI17497 AAI30629 AAY29059 BAA92005 BAA92434 BAA92493 BAD11774 BAD11775 BAD12265 BAD12266 BAD12267 BAG65196 CAB70703 EAW91842
RNA Seq Atlas 50484