Homo sapiens Gene: ADH1A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-31214.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ADH1A | ||||||||||||||||||
Gene Name | alcohol dehydrogenase 1A (class I), alpha polypeptide | ||||||||||||||||||
Synonyms | ADH1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000187758 | ||||||||||||||||||
Encoded Proteins |
alcohol dehydrogenase 1A (class I), alpha polypeptide
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 4:99276367-99291028 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q23 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Abacavir metabolism pathway
Ethanol oxidation pathway
Abacavir transport and metabolism pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
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KEGG |
Glycolysis / Gluconeogenesis pathway
Retinol metabolism pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
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INOH |
Tyrosine metabolism pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P07327 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 124 | ||||||||||||||||||
UniGene | Hs.654433 | ||||||||||||||||||
RefSeq | NM_000667 | ||||||||||||||||||
HUGO | HGNC:249 | ||||||||||||||||||
OMIM | 103700 | ||||||||||||||||||
CCDS | CCDS3648 | ||||||||||||||||||
HPRD | 00063 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK290558 AY948115 BC074738 BC117442 BC126306 BT019812 CH471057 M12271 M12963 M37066 | ||||||||||||||||||
GenPept | AAA51590 AAA51591 AAA68131 AAH74738 AAI17443 AAI26307 AAV38615 AAX20115 BAF83247 EAX06094 | ||||||||||||||||||
RNA Seq Atlas | 124 | ||||||||||||||||||