Homo sapiens Gene: ADH1A
Summary
InnateDB Gene IDBG-31214.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH1A
Gene Name alcohol dehydrogenase 1A (class I), alpha polypeptide
Synonyms ADH1;
Species Homo sapiens
Ensembl Gene ENSG00000187758
Encoded Proteins
alcohol dehydrogenase 1A (class I), alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99276367-99291028
Strand Reverse strand
Band q23
Transcripts
ENST00000209668 ENSP00000209668
ENST00000503461
ENST00000511656
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004024 alcohol dehydrogenase activity, zinc-dependent
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006066 alcohol metabolic process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0017144 drug metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Abacavir metabolism pathway
Abacavir transport and metabolism pathway
Metabolism pathway
Biological oxidations pathway
Ethanol oxidation pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P07327
TrEMBL
UniProt Splice Variant
Entrez Gene 124
UniGene Hs.654433
RefSeq NM_000667
HUGO HGNC:249
OMIM 103700
CCDS CCDS3648
HPRD
IMGT
EMBL AK290558 AY948115 BC074738 BC117442 BC126306 BT019812 CH471057 M12271 M12963 M37066
GenPept AAA51590 AAA51591 AAA68131 AAH74738 AAI17443 AAI26307 AAV38615 AAX20115 BAF83247 EAX06094
RNA Seq Atlas 124