InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMAD2

Summary

InnateDB Gene

IDBG-3127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD2

Gene Name

SMAD family member 2

Synonyms

hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2

Species

Homo sapiens

Ensembl Gene

ENSG00000175387

Encoded Proteins

IDBP-3129

SMAD family member 2

IDBP-3131

SMAD family member 2

IDBP-294787

SMAD family member 2

IDBP-727455

IDBP-727879

IDBP-727215

IDBP-726911

IDBP-726049

IDBP-726508

IDBP-726936

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:47808957-47931146

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000262160	ENSP00000262160
ENST00000356825	ENSP00000349282
ENST00000402690	ENSP00000384449
ENST00000585978	ENSP00000468732
ENST00000587353
ENST00000587269	ENSP00000466254
ENST00000591214	ENSP00000467075
ENST00000587421	ENSP00000468202
ENST00000586514	ENSP00000465355
ENST00000586040	ENSP00000466193
ENST00000589877	ENSP00000465971
ENST00000586487

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 432 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	432 [view]
Protein-Protein	419 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	6 [view]
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019902	phosphatase binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0033613	activating transcription factor binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0035326	enhancer binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007183	SMAD protein complex assembly
GO:0007352	zygotic specification of dorsal/ventral axis
GO:0007369	gastrulation
GO:0007389	pattern specification process
GO:0007492	endoderm development
GO:0007507	heart development
GO:0008285	negative regulation of cell proliferation
GO:0009749	response to glucose
GO:0009791	post-embryonic development
GO:0009880	embryonic pattern specification
GO:0009952	anterior/posterior pattern specification
GO:0010467	gene expression
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030073	insulin secretion
GO:0030324	lung development
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0031016	pancreas development
GO:0031053	primary miRNA processing
GO:0032924	activin receptor signaling pathway
GO:0035265	organ growth
GO:0035556	intracellular signal transduction
GO:0038092	nodal signaling pathway
GO:0045165	cell fate commitment
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048340	paraxial mesoderm morphogenesis
GO:0048589	developmental growth
GO:0048617	embryonic foregut morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0051098	regulation of binding
GO:0060021	palate development
GO:0060039	pericardium development
GO:0070723	response to cholesterol
GO:1900224	positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0032444	activin responsive factor complex
GO:0043234	protein complex
GO:0071141	SMAD protein complex
GO:0071144	SMAD2-SMAD3 protein complex