Homo sapiens Gene: MMP2
Summary
InnateDB Gene IDBG-31271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP2
Gene Name matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Synonyms CLG4; CLG4A; MMP-II; MONA; TBE-1;
Species Homo sapiens
Ensembl Gene ENSG00000087245
Encoded Proteins
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55389700-55506691
Strand Forward strand
Band q12.2
Transcripts
ENST00000219070 ENSP00000219070
ENST00000437642 ENSP00000394237
ENST00000543485 ENSP00000444143
ENST00000570308 ENSP00000461421
ENST00000564864 ENSP00000456096
ENST00000568715 ENSP00000457949
ENST00000570283 ENSP00000456518
ENST00000566564 ENSP00000461915
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 29 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001955 blood vessel maturation
GO:0001957 intramembranous ossification
GO:0006508 proteolysis
GO:0007566 embryo implantation
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0044267 cellular protein metabolic process
GO:0045089 positive regulation of innate immune response
GO:0048705 skeletal system morphogenesis
GO:0060325 face morphogenesis
GO:0060346 bone trabecula formation
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0030017 sarcomere
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Axon guidance pathway
Metabolism of proteins pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
Collagen degradation pathway
KEGG
Leukocyte transendothelial migration pathway
GnRH signaling pathway pathway
Pathways in cancer pathway
Bladder cancer pathway
INOH
PID BIOCARTA
Inhibition of matrix metalloproteinases [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
LPA receptor mediated events
Direct p53 effectors
ATF-2 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Angiopoietin receptor Tie2-mediated signaling
Plasma membrane estrogen receptor signaling
FOXM1 transcription factor network
amb2 Integrin signaling
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513617 Hs.667363
RefSeq NM_001127891 NM_004530
HUGO
OMIM
CCDS CCDS10752 CCDS45487
HPRD 00386
IMGT
EMBL
GenPept
RNA Seq Atlas