Homo sapiens Gene: ZFYVE16
Summary
InnateDB Gene IDBG-31374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE16
Gene Name zinc finger, FYVE domain containing 16
Synonyms PPP1R69;
Species Homo sapiens
Ensembl Gene ENSG00000039319
Encoded Proteins
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
zinc finger, FYVE domain containing 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004 [PubMed 14613930]).[supplied by OMIM, Mar 2008]
This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:80408013-80479350
Strand Forward strand
Band q14.1
Transcripts
ENST00000338008 ENSP00000337159
ENST00000510158 ENSP00000423663
ENST00000505560 ENSP00000426848
ENST00000512558
ENST00000509562 ENSP00000422356
ENST00000510995
ENST00000512442
ENST00000511050
ENST00000511829
ENST00000509558 ENSP00000426536
ENST00000507548 ENSP00000421785
ENST00000512907
ENST00000513789 ENSP00000426500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008565 protein transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006622 protein targeting to lysosome
GO:0007165 signal transduction
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0030100 regulation of endocytosis
GO:0030509 BMP signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
REACTOME
Signal Transduction pathway
Signaling by BMP pathway
KEGG
Endocytosis pathway
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
BMP receptor signaling
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.482660 Hs.660410 Hs.709921
RefSeq NM_001105251 NM_001284236 NM_014733 XM_005248632
HUGO
OMIM
CCDS CCDS4050
HPRD 10319
IMGT
EMBL
GenPept
RNA Seq Atlas