InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IGF1R

Summary

InnateDB Gene

IDBG-31432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF1R

Gene Name

insulin-like growth factor 1 receptor

Synonyms

CD221; IGFIR; IGFR; JTK13

Species

Homo sapiens

Ensembl Gene

ENSG00000140443

Encoded Proteins

IDBP-31434

insulin-like growth factor 1 receptor

IDBP-586759

insulin-like growth factor 1 receptor

IDBP-590016

insulin-like growth factor 1 receptor

IDBP-591084

insulin-like growth factor 1 receptor

IDBP-745321

IDBP-599793

insulin-like growth factor 1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10747872

IGF1R is able to mediate activation of STAT3 in vitro and in vivo and the JAKs are essential for this process of activation.

Entrez Gene

Summary

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:98648971-98964530

Strand

Forward strand

Band

q26.3

Transcripts

ENST00000268035	ENSP00000268035
ENST00000558762	ENSP00000453007
ENST00000559925
ENST00000558355	ENSP00000453630
ENST00000557938
ENST00000560186
ENST00000560277
ENST00000557873
ENST00000558898	ENSP00000454115
ENST00000560432
ENST00000558947
ENST00000559582
ENST00000560144	ENSP00000456950
ENST00000561049
ENST00000560343
ENST00000560972	ENSP00000453180
ENST00000558751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	118 [view]
Protein-Protein	116 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005010	insulin-like growth factor-activated receptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031994	insulin-like growth factor I binding
GO:0042802	identical protein binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043559	insulin binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030010	establishment of cell polarity
GO:0030238	male sex determination
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0031017	exocrine pancreas development
GO:0031175	neuron projection development
GO:0032467	positive regulation of cytokinesis
GO:0033197	response to vitamin E
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043409	negative regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045740	positive regulation of DNA replication
GO:0045840	positive regulation of mitosis
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051054	positive regulation of DNA metabolic process
GO:0051262	protein tetramerization
GO:0051291	protein heterooligomerization
GO:0051389	inactivation of MAPKK activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0051898	negative regulation of protein kinase B signaling
GO:0060740	prostate gland epithelium morphogenesis
GO:0090031	positive regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex