Homo sapiens Gene: IGF1R
Summary
InnateDB Gene IDBG-31432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF1R
Gene Name insulin-like growth factor 1 receptor
Synonyms CD221; IGFIR; IGFR; JTK13;
Species Homo sapiens
Ensembl Gene ENSG00000140443
Encoded Proteins
insulin-like growth factor 1 receptor
insulin-like growth factor 1 receptor
insulin-like growth factor 1 receptor
insulin-like growth factor 1 receptor
insulin-like growth factor 1 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IGF1R is able to mediate activation of STAT3 in vitro and in vivo and the JAKs are essential for this process of activation.
Entrez Gene
Summary This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:98648971-98964530
Strand Forward strand
Band q26.3
Transcripts
ENST00000268035 ENSP00000268035
ENST00000558762 ENSP00000453007
ENST00000559925
ENST00000558355 ENSP00000453630
ENST00000557938
ENST00000560186
ENST00000560277
ENST00000557873
ENST00000558898 ENSP00000454115
ENST00000560432
ENST00000558947
ENST00000559582
ENST00000560144 ENSP00000456950
ENST00000561049
ENST00000560343
ENST00000560972 ENSP00000453180
ENST00000558751
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 118 [view]
Protein-Protein 116 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031994 insulin-like growth factor I binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007409 axonogenesis
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030010 establishment of cell polarity
GO:0030238 male sex determination
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0031017 exocrine pancreas development
GO:0031175 neuron projection development
GO:0032467 positive regulation of cytokinesis
GO:0033197 response to vitamin E
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0045740 positive regulation of DNA replication
GO:0045840 positive regulation of mitosis
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051054 positive regulation of DNA metabolic process
GO:0051262 protein tetramerization
GO:0051291 protein heterooligomerization
GO:0051389 inactivation of MAPKK activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060740 prostate gland epithelium morphogenesis
GO:0090031 positive regulation of steroid hormone biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
TSH pathway
REACTOME
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
SHC-related events triggered by IGF1R pathway
Signal Transduction pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
KEGG
Oocyte meiosis pathway
Endocytosis pathway
Focal adhesion pathway
Adherens junction pathway
Long-term depression pathway
Progesterone-mediated oocyte maturation pathway
Pathways in cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
INOH
IGF1 signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
Integrins in angiogenesis
IGF1 pathway
Plasma membrane estrogen receptor signaling
SHP2 signaling
Stabilization and expansion of the E-cadherin adherens junction
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643120 Hs.713906 Hs.714012 Hs.714162
RefSeq NM_000875 NM_001291858 XM_005254896 XM_005254897 XM_006720487
HUGO
OMIM
CCDS CCDS10378 CCDS73785
HPRD 00932
IMGT
EMBL
GenPept
RNA Seq Atlas