InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTTP

Summary

InnateDB Gene

IDBG-31441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTTP

Gene Name

microsomal triglyceride transfer protein

Synonyms

ABL; MTP

Species

Homo sapiens

Ensembl Gene

ENSG00000138823

Encoded Proteins

IDBP-31445

microsomal triglyceride transfer protein

IDBP-374894

microsomal triglyceride transfer protein

IDBP-374901

microsomal triglyceride transfer protein

IDBP-477293

microsomal triglyceride transfer protein

IDBP-484037

microsomal triglyceride transfer protein

IDBP-474084

microsomal triglyceride transfer protein

IDBP-483713

microsomal triglyceride transfer protein

IDBP-477490

microsomal triglyceride transfer protein

IDBP-481287

microsomal triglyceride transfer protein

IDBP-473612

microsomal triglyceride transfer protein

IDBP-476018

microsomal triglyceride transfer protein

IDBP-809182

microsomal triglyceride transfer protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:99563761-99623999

Strand

Forward strand

Band

q23

Transcripts

ENST00000265517	ENSP00000265517
ENST00000457717	ENSP00000400821
ENST00000422897	ENSP00000407350
ENST00000513404	ENSP00000424972
ENST00000505142	ENSP00000425987
ENST00000506883	ENSP00000426755
ENST00000515141	ENSP00000425642
ENST00000511045	ENSP00000427679
ENST00000504724	ENSP00000422667
ENST00000511610	ENSP00000422178
ENST00000505094	ENSP00000422782
ENST00000619629	ENSP00000482850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0034185	apolipoprotein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006497	protein lipidation
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0044281	small molecule metabolic process
GO:0051592	response to calcium ion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016323	basolateral plasma membrane
GO:0031526	brush border membrane
GO:0031528	microvillus membrane
GO:0031988	membrane-bounded vesicle
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028158

View Gene Order

ENSBTAG00000011944

Not yet available

Pathways

NETPATH

REACTOME

REACT_6841

Chylomicron-mediated lipid transport pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_6823

Lipoprotein metabolism pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

hsa04975

Fat digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

D6RBJ4

UniProt Splice Variant

Entrez Gene

4547

UniGene

Hs.195799 Hs.739646

RefSeq

NM_000253 NM_001300785 XM_005263025

HUGO

HGNC:7467

OMIM

157147

CCDS

CCDS3651 CCDS75169

HPRD

01144

IMGT

EMBL

AC083902

GenPept

RNA Seq Atlas

4547