Homo sapiens Gene: MSH3
Summary
InnateDB Gene IDBG-31502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSH3
Gene Name mutS homolog 3 (E. coli)
Synonyms DUP; MRP1;
Species Homo sapiens
Ensembl Gene ENSG00000113318
Encoded Proteins
mutS homolog 3 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:80654648-80876460
Strand Forward strand
Band q14.1
Transcripts
ENST00000265081 ENSP00000265081
ENST00000512531
ENST00000512258
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000403 Y-form DNA binding
GO:0000404 heteroduplex DNA loop binding
GO:0000406 double-strand/single-strand DNA junction binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0019237 centromeric DNA binding
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032139 dinucleotide insertion or deletion binding
GO:0032142 single guanine insertion binding
GO:0032181 dinucleotide repeat insertion binding
GO:0032357 oxidized purine DNA binding
Biological Process
GO:0000710 meiotic mismatch repair
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007131 reciprocal meiotic recombination
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0043570 maintenance of DNA repeat elements
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
Cellular Component
GO:0000228 nuclear chromosome
GO:0005634 nucleus
GO:0016020 membrane
GO:0032302 MutSbeta complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
DNA Repair pathway
KEGG
Mismatch repair pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P20585
TrEMBL
UniProt Splice Variant
Entrez Gene 4437
UniGene Hs.280987
RefSeq NM_002439
HUGO HGNC:7326
OMIM 600887
CCDS CCDS34195
HPRD 02931
IMGT
EMBL AC008434 AC010270 AC022493 AY275681 BC011817 BC130434 BC130436 D61419 J04810 U61981
GenPept AAB06045 AAB47281 AAH11817 AAI30435 AAI30437 AAP13535 BAD27111
RNA Seq Atlas 4437