InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MSH3

Summary

InnateDB Gene

IDBG-31502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSH3

Gene Name

mutS homolog 3 (E. coli)

Synonyms

DUP; MRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000113318

Encoded Proteins

IDBP-31504

mutS homolog 3 (E. coli)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:80654648-80876460

Strand

Forward strand

Band

q14.1

Transcripts

ENST00000265081	ENSP00000265081
ENST00000512531
ENST00000512258

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000403	Y-form DNA binding
GO:0000404	heteroduplex DNA loop binding
GO:0000406	double-strand/single-strand DNA junction binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0019237	centromeric DNA binding
GO:0019899	enzyme binding
GO:0030983	mismatched DNA binding
GO:0032139	dinucleotide insertion or deletion binding
GO:0032142	single guanine insertion binding
GO:0032181	dinucleotide repeat insertion binding
GO:0032357	oxidized purine DNA binding

Biological Process

GO:0000710	meiotic mismatch repair
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0007131	reciprocal meiotic recombination
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0043570	maintenance of DNA repeat elements
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity

Cellular Component

GO:0000228	nuclear chromosome
GO:0005634	nucleus
GO:0016020	membrane
GO:0032302	MutSbeta complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000014850

View Gene Order

ENSBTAG00000007684

Not yet available

Pathways

NETPATH

REACTOME

REACT_228019

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_228013

Mismatch Repair pathway

REACT_216

DNA Repair pathway

KEGG

hsa05210

Colorectal cancer pathway

hsa03430

Mismatch repair pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

P20585

TrEMBL

UniProt Splice Variant

Entrez Gene

4437

UniGene

Hs.280987

RefSeq

NM_002439

HUGO

HGNC:7326

OMIM

600887

CCDS

CCDS34195

HPRD

02931

IMGT

EMBL

AC008434 AC010270 AC022493 AY275681 BC011817 BC130434 BC130436 D61419 J04810 U61981

GenPept

AAB06045 AAB47281 AAH11817 AAI30435 AAI30437 AAP13535 BAD27111

RNA Seq Atlas

4437