Homo sapiens Gene: PPP3CA
Summary
InnateDB Gene IDBG-31818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP3CA
Gene Name protein phosphatase 3, catalytic subunit, alpha isozyme
Synonyms CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B;
Species Homo sapiens
Ensembl Gene ENSG00000138814
Encoded Proteins
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
protein phosphatase 3, catalytic subunit, alpha isozyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PPP3CA (calcineurin) is a serine/threonine phosphatase that is activated by calcium and calmodulin that promotes HIF1A expression by dephosphorylating RACK1 and blocking RACK1 dimerization.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:101023409-101348278
Strand Reverse strand
Band q24
Transcripts
ENST00000323055 ENSP00000320580
ENST00000394854 ENSP00000378323
ENST00000394853 ENSP00000378322
ENST00000512215 ENSP00000422781
ENST00000507176 ENSP00000422990
ENST00000492351 ENSP00000426565
ENST00000510292
ENST00000529324 ENSP00000431619
ENST00000525819 ENSP00000434599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 64 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008144 drug binding
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0014883 transition between fast and slow fiber
GO:0016311 dephosphorylation
GO:0019722 calcium-mediated signaling
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033555 multicellular organismal response to stress
GO:0035690 cellular response to drug
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042110 T cell activation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046676 negative regulation of insulin secretion
GO:0048741 skeletal muscle fiber development
GO:0050804 regulation of synaptic transmission
GO:0051592 response to calcium ion
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005955 calcineurin complex
GO:0016020 membrane
GO:0030018 Z disc
GO:0042383 sarcolemma
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL3 pathway
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Opioid Signalling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
DARPP-32 events pathway
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Oocyte meiosis pathway
Apoptosis pathway
Wnt signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Regulation of pgc-1a [Biocarta view]
Bcr signaling pathway [Biocarta view]
Endocytotic role of ndk phosphins and dynamin [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Nitric oxide signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
BCR signaling pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435512 Hs.706046
RefSeq NM_000944 NM_001130691 NM_001130692
HUGO
OMIM
CCDS CCDS34037 CCDS47113 CCDS47114
HPRD 00234
IMGT
EMBL
GenPept
RNA Seq Atlas