InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUDT21

Summary

InnateDB Gene

IDBG-31912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT21

Gene Name

nudix (nucleoside diphosphate linked moiety X)-type motif 21

Synonyms

CFIM25; CPSF5

Species

Homo sapiens

Ensembl Gene

ENSG00000167005

Encoded Proteins

IDBP-31914

nudix (nucleoside diphosphate linked moiety X)-type motif 21

IDBP-748728

IDBP-750847

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one subunit of a cleavage factor required for 3\' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3\' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:56429133-56452199

Strand

Reverse strand

Band

q13

Transcripts

ENST00000300291	ENSP00000300291
ENST00000563362
ENST00000567110
ENST00000568822	ENSP00000457942
ENST00000566340	ENSP00000454790
ENST00000563860
ENST00000612596

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 139 experimentally validated interaction(s) in this database.

Experimentally validated
Total	139 [view]
Protein-Protein	138 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0017091	AU-rich element binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing
GO:0051262	protein tetramerization