Version 5.4
Homo sapiens Gene: EPO
Summary
InnateDB Gene IDBG-31941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPO
Gene Name erythropoietin
Synonyms EP; MVCD2
Species Homo sapiens
Ensembl Gene ENSG00000130427
Encoded Proteins
IDBP-31943
erythropoietin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100720800-100723700
Strand Forward strand
Band q22.1
Transcripts
ENST00000252723 ENSP00000252723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005128 erythropoietin receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0030295 protein kinase activator activity
Biological Process
GO:0001666 response to hypoxia
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0009651 response to salt stress
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0018105 peptidyl-serine phosphorylation
GO:0030218 erythrocyte differentiation
GO:0032496 response to lipopolysaccharide
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033189 response to vitamin A
GO:0033574 response to testosterone
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042541 hemoglobin biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043249 erythrocyte maturation
GO:0043627 response to estrogen
GO:0045666 positive regulation of neuron differentiation
GO:0045740 positive regulation of DNA replication
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048678 response to axon injury
GO:0051602 response to electrical stimulus
GO:0055093 response to hyperoxia
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070555 response to interleukin-1
GO:0071456 cellular response to hypoxia
GO:0071474 cellular hyperosmotic response
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902251 negative regulation of erythrocyte apoptotic process
GO:2001258 negative regulation of cation channel activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029711
View Gene Order
ENSBTAG00000003430
Not yet available
Pathways
NETPATH
REACTOME
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
epopathway
EPO signaling pathway
hif2pathway
HIF-2-alpha transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt P01588
TrEMBL B7ZKK5 G9JKG7 U3MHQ9
UniProt Splice Variant
Entrez Gene 2056
UniGene Hs.2303
RefSeq NM_000799
HUGO HGNC:3415
OMIM 133170
CCDS CCDS5705
HPRD
IMGT
EMBL AC009488 AF053356 AF202306 AF202307 AF202308 AF202311 AF202312 AF202313 AF202314 AH009004 BC093628 BC111937 BC143225 CH471091 JN849371 KF178447 M11319 S65458 X02157 X02158
GenPept AAA52400 AAC78791 AAD13964 AAF17572 AAF23132 AAF23133 AAF23134 AAH93628 AAI11938 AAI43226 AAP22357 AEU17862 AGW15567 CAA26094 CAA26095 EAW76493
RNA Seq Atlas 2056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca