Homo sapiens Gene: MAP4
Summary
InnateDB Gene IDBG-32054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4
Gene Name microtubule-associated protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047849
Encoded Proteins
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
microtubule-associated protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:47850690-48089272
Strand Reverse strand
Band p21.31
Transcripts
ENST00000360240 ENSP00000353375
ENST00000335271 ENSP00000334770
ENST00000383736 ENSP00000373242
ENST00000395734 ENSP00000379083
ENST00000429422 ENSP00000416743
ENST00000426837 ENSP00000407602
ENST00000420772 ENSP00000409731
ENST00000423088 ENSP00000415689
ENST00000434267 ENSP00000402767
ENST00000439356 ENSP00000397414
ENST00000477765
ENST00000462206
ENST00000497735
ENST00000482752
ENST00000468075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007052 mitotic spindle organization
GO:0051012 microtubule sliding
GO:0051294 establishment of spindle orientation
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt P27816
TrEMBL
UniProt Splice Variant
Entrez Gene 4134
UniGene Hs.517949 Hs.603055
RefSeq NM_001134364 NM_002375 NM_030885 XM_006713160 XM_006713145
HUGO HGNC:6862
OMIM 157132
CCDS CCDS46818 CCDS33750 CCDS46821
HPRD 01141
IMGT
EMBL AB209377 AC124916 AC139667 AK054696 AK125245 BC008715 BC012794 BC015149 BC051843 CH471055 CR749544 M64571 U19727
GenPept AAA59553 AAA67361 AAH08715 AAH12794 AAH15149 AAH51843 BAB70795 BAC86099 BAD92614 CAH18346 EAW64839
RNA Seq Atlas 4134