Version 5.4
Homo sapiens Gene: UBE2D3
Summary
InnateDB Gene IDBG-32113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2D3
Gene Name ubiquitin-conjugating enzyme E2D 3
Synonyms E2(17)KB3; UBC4/5; UBCH5C
Species Homo sapiens
Ensembl Gene ENSG00000109332
Encoded Proteins
IDBP-32115
ubiquitin-conjugating enzyme E2D 3
IDBP-32117
ubiquitin-conjugating enzyme E2D 3
IDBP-32119
ubiquitin-conjugating enzyme E2D 3
IDBP-32121
ubiquitin-conjugating enzyme E2D 3
IDBP-32123
ubiquitin-conjugating enzyme E2D 3
IDBP-51479
ubiquitin-conjugating enzyme E2D 3
IDBP-240836
ubiquitin-conjugating enzyme E2D 3
IDBP-240838
ubiquitin-conjugating enzyme E2D 3
IDBP-240840
ubiquitin-conjugating enzyme E2D 3
IDBP-375164
ubiquitin-conjugating enzyme E2D 3
IDBP-475460
ubiquitin-conjugating enzyme E2D 3
IDBP-475020
ubiquitin-conjugating enzyme E2D 3
IDBP-476998
ubiquitin-conjugating enzyme E2D 3
IDBP-482609
ubiquitin-conjugating enzyme E2D 3
IDBP-484975
ubiquitin-conjugating enzyme E2D 3
IDBP-481459
ubiquitin-conjugating enzyme E2D 3
IDBP-477642
ubiquitin-conjugating enzyme E2D 3
IDBP-479896
ubiquitin-conjugating enzyme E2D 3
IDBP-485170
ubiquitin-conjugating enzyme E2D 3
IDBP-473771
ubiquitin-conjugating enzyme E2D 3
IDBP-485084
ubiquitin-conjugating enzyme E2D 3
IDBP-474815
ubiquitin-conjugating enzyme E2D 3
IDBP-483921
ubiquitin-conjugating enzyme E2D 3
IDBP-473780
ubiquitin-conjugating enzyme E2D 3
IDBP-482548
ubiquitin-conjugating enzyme E2D 3
IDBP-807082
ubiquitin-conjugating enzyme E2D 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:102794383-102868896
Strand Reverse strand
Band q24
Transcripts
ENST00000338145 ENSP00000337208
ENST00000350435 ENSP00000337262
ENST00000321805 ENSP00000318494
ENST00000343106 ENSP00000345285
ENST00000357194 ENSP00000349722
ENST00000349311 ENSP00000344069
ENST00000394804 ENSP00000378283
ENST00000394803 ENSP00000378282
ENST00000394801 ENSP00000378280
ENST00000453744 ENSP00000396901
ENST00000508474
ENST00000503742
ENST00000504211 ENSP00000426620
ENST00000505009
ENST00000505207 ENSP00000426586
ENST00000507845 ENSP00000424359
ENST00000502404 ENSP00000421904
ENST00000508635 ENSP00000427270
ENST00000505307 ENSP00000422939
ENST00000510129 ENSP00000422134
ENST00000508476 ENSP00000424710
ENST00000502563 ENSP00000421794
ENST00000508238 ENSP00000423487
ENST00000514755 ENSP00000423692
ENST00000508974 ENSP00000423324
ENST00000502690 ENSP00000425762
ENST00000510599
ENST00000508818
ENST00000503418 ENSP00000423869
ENST00000508249 ENSP00000421310
ENST00000513098
ENST00000503282
ENST00000618836 ENSP00000481600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 248 experimentally validated interaction(s) in this database.
Experimentally validated
Total 248 [view]
Protein-Protein 244 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000209 protein polyubiquitination
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006915 apoptotic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0016567 protein ubiquitination
GO:0030509 BMP signaling pathway
GO:0032480 negative regulation of type I interferon production
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_12034
Signaling by BMP pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_120956
Cellular responses to stress pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
bard1pathway
BARD1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518773 Hs.595430 Hs.595816 Hs.598998 Hs.604237 Hs.732195
RefSeq NM_001300795 NM_003340 NM_181886 NM_181887 NM_181888 NM_181889 NM_181890 NM_181891 NM_181892 NM_181893 XM_005263200 XM_005263205 XM_006714297 XM_006714298 XM_006714299 XM_006714300
HUGO
OMIM
CCDS CCDS3659 CCDS3660 CCDS3661 CCDS75172
HPRD 04269
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca