Homo sapiens Gene: RACGAP1
Summary
InnateDB Gene IDBG-32209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RACGAP1
Gene Name Rac GTPase activating protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161800
Encoded Proteins
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Rac GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:49976923-50033136
Strand Reverse strand
Band q13.12
Transcripts
ENST00000312377 ENSP00000309871
ENST00000427314 ENSP00000404190
ENST00000454520 ENSP00000404808
ENST00000548961 ENSP00000446889
ENST00000551016 ENSP00000449374
ENST00000547905 ENSP00000449370
ENST00000549342 ENSP00000449565
ENST00000547061
ENST00000548320 ENSP00000448507
ENST00000548598 ENSP00000449574
ENST00000552310 ENSP00000448697
ENST00000548158
ENST00000550149 ENSP00000446642
ENST00000546786 ENSP00000447429
ENST00000546595 ENSP00000449963
ENST00000551145 ENSP00000450064
ENST00000548824 ENSP00000449170
ENST00000551260 ENSP00000448860
ENST00000548644 ENSP00000449620
ENST00000546723 ENSP00000449669
ENST00000552921 ENSP00000447393
ENST00000552157 ENSP00000448968
ENST00000548247 ENSP00000450074
ENST00000546764 ENSP00000447177
ENST00000551876 ENSP00000449186
ENST00000549777 ENSP00000448707
ENST00000550651 ENSP00000449959
ENST00000552004 ENSP00000448136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 50 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0043014 alpha-tubulin binding
GO:0043015 gamma-tubulin binding
GO:0046872 metal ion binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0000915 cytokinesis, actomyosin contractile ring assembly
GO:0007018 microtubule-based movement
GO:0007108 cytokinesis, initiation of separation
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007283 spermatogenesis
GO:0007405 neuroblast proliferation
GO:0007596 blood coagulation
GO:0008272 sulfate transport
GO:0009790 embryo development
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467 positive regulation of cytokinesis
GO:0035556 intracellular signal transduction
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051256 spindle midzone assembly involved in mitosis
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0030496 midbody
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032154 cleavage furrow
GO:0051233 spindle midzone
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
GO:0097149 centralspindlin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
MHC class II antigen presentation pathway
Kinesins pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Rho GTPase cycle pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RAC1 activity
RAC1 signaling pathway
Regulation of CDC42 activity
Aurora B signaling
Cross-References
SwissProt Q9H0H5
TrEMBL A0A024R136 F8VQZ5 F8VRD2 F8VRL2 F8VS54 F8VUW9 F8VV37 F8VV39 F8VV47 F8VWX0 F8VWY4 F8VYH6 F8VZ66 F8W0L1
UniProt Splice Variant
Entrez Gene 29127
UniGene Hs.505469 Hs.618868 Hs.650500
RefSeq NM_001126104 NM_013277 NM_001126103 XM_006719360 XM_006719359 XM_005268815 XM_005268812 XM_005268816 XM_005268813 XM_005268814 XM_005268811
HUGO HGNC:9804
OMIM 604980
CCDS CCDS8795
HPRD 05402
IMGT
EMBL AB030251 AB040911 AC025154 AK000733 AL136794 BC024144 BC032754 CH471111 CR533565
GenPept AAH24144 AAH32754 BAA90247 BAA91347 BAA96002 CAB66728 CAG38596 EAW58113 EAW58114 EAW58115
RNA Seq Atlas 29127