Version 5.4
Homo sapiens Gene: EIF3E
Summary
InnateDB Gene IDBG-32393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3E
Gene Name eukaryotic translation initiation factor 3, subunit E
Synonyms eIF3-p46; EIF3-P48; EIF3S6; INT6
Species Homo sapiens
Ensembl Gene ENSG00000104408
Encoded Proteins
IDBP-32395
eukaryotic translation initiation factor 3, subunit E
IDBP-474953
eukaryotic translation initiation factor 3, subunit E
IDBP-479291
eukaryotic translation initiation factor 3, subunit E
IDBP-476190
eukaryotic translation initiation factor 3, subunit E
IDBP-480840
eukaryotic translation initiation factor 3, subunit E
IDBP-484773
eukaryotic translation initiation factor 3, subunit E
IDBP-473714
eukaryotic translation initiation factor 3, subunit E
IDBP-479654
eukaryotic translation initiation factor 3, subunit E
IDBP-477514
eukaryotic translation initiation factor 3, subunit E
IDBP-476758
eukaryotic translation initiation factor 3, subunit E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:108201216-108435333
Strand Reverse strand
Band q23.1
Transcripts
ENST00000220849 ENSP00000220849
ENST00000523674
ENST00000522352 ENSP00000428170
ENST00000519030 ENSP00000428796
ENST00000521614
ENST00000519517
ENST00000519627 ENSP00000430839
ENST00000519413
ENST00000522445 ENSP00000430709
ENST00000523646
ENST00000521440 ENSP00000430152
ENST00000518442
ENST00000518100 ENSP00000429327
ENST00000522887 ENSP00000430649
ENST00000521297 ENSP00000429968
ENST00000518345 ENSP00000430678
ENST00000518634
ENST00000522088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 145 [view]
Protein-Protein 142 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
GO:0045947 negative regulation of translational initiation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0016605 PML body
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022336
View Gene Order
ENSBTAG00000006702
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405590 Hs.575544 Hs.710451
RefSeq NM_001568
HUGO
OMIM
CCDS CCDS6308
HPRD 03734
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca