Homo sapiens Gene: RFX1
Summary
InnateDB Gene IDBG-32668.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFX1
Gene Name regulatory factor X, 1 (influences HLA class II expression)
Synonyms EFC; RFX;
Species Homo sapiens
Ensembl Gene ENSG00000132005
Encoded Proteins
regulatory factor X, 1 (influences HLA class II expression)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:13961538-14007039
Strand Reverse strand
Band p13.12
Transcripts
ENST00000254325 ENSP00000254325
ENST00000586913
ENST00000589239
ENST00000589760
ENST00000589937
ENST00000588520
ENST00000588885 ENSP00000464960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006955 immune response
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL K7EIZ8
UniProt Splice Variant
Entrez Gene 5989
UniGene Hs.655215 Hs.73677 Hs.739376
RefSeq NM_002918 XM_006722831 XM_006722830 XM_006722829
HUGO HGNC:9982
OMIM 600006
CCDS CCDS12301
HPRD 02476
IMGT
EMBL AC020916 AC022098
GenPept
RNA Seq Atlas 5989