Version 5.4
Homo sapiens Gene: PRKACA
Summary
InnateDB Gene IDBG-32929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKACA
Gene Name protein kinase, cAMP-dependent, catalytic, alpha
Synonyms PKACA;
Species Homo sapiens
Ensembl Gene ENSG00000072062
Encoded Proteins
IDBP-32931
protein kinase, cAMP-dependent, catalytic, alpha
IDBP-761009
IDBP-760734
IDBP-766132
IDBP-761325
IDBP-766213
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25028512
MAP3K7 (TAK1) Ser412 phosphorylation is regulated by PRKACA and PRKX, and is essential for proper signalling, as well as proinflammatory cytokine induction by TLR/IL-1R activation.
Entrez Gene
Summary cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14091688-14118084
Strand Reverse strand
Band p13.12
Transcripts
ENST00000308677 ENSP00000309591
ENST00000350356
ENST00000536649
ENST00000587372 ENSP00000468352
ENST00000588209
ENST00000589994 ENSP00000466651
ENST00000590853 ENSP00000466976
ENST00000587533
ENST00000593092 ENSP00000466289
ENST00000589284 ENSP00000466660
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 162 [view]
Protein-Protein 160 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0034237 protein kinase A regulatory subunit binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001707 mesoderm formation
GO:0001843 neural tube closure
GO:0002027 regulation of heart rate
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006468 protein phosphorylation
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007596 blood coagulation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019433 triglyceride catabolic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043393 regulation of protein binding
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045667 regulation of osteoblast differentiation
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048240 sperm capacitation
GO:0050796 regulation of insulin secretion
GO:0050804 regulation of synaptic transmission
GO:0051480 cytosolic calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070613 regulation of protein processing
GO:0071158 positive regulation of cell cycle arrest
GO:0071333 cellular response to glucose stimulus
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071872 cellular response to epinephrine stimulus
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0005952 cAMP-dependent protein kinase complex
GO:0016020 membrane
GO:0031588 AMP-activated protein kinase complex
GO:0031594 neuromuscular junction
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
GO:0097225 sperm midpiece
GO:0097546 ciliary base
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000005469
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000006642
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_8
Wnt pathway
NetPath_10
Hedgehog pathway
NetPath_15
IL3 pathway
NetPath_23
TSH pathway
NetPath_25
FSH pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_1505
Integration of energy metabolism pathway
REACT_23898
Rap1 signalling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_9053
CaM pathway pathway
REACT_11061
Signalling by NGF pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_15497
PKA-mediated phosphorylation of CREB pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_147814
DAP12 signaling pathway
REACT_20625
CREB phosphorylation through the activation of Adenylate Cyclase pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_9417
Signaling by EGFR pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_14797
Signaling by GPCR pathway
REACT_1525
PKA-mediated phosphorylation of key metabolic factors pathway
REACT_6802
Innate Immune System pathway
REACT_15426
PLC beta mediated events pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_15295
Opioid Signalling pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_15530
PKA activation pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15526
G-protein mediated events pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_1520
Gluconeogenesis pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_6900
Immune System pathway
REACT_17025
Downstream signal transduction pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_15479
Centrosome maturation pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_2203
G2/M Transition pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_9470
Signaling by FGFR pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_16888
Signaling by PDGF pathway
REACT_1946
PKA activation in glucagon signalling pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111217
Metabolism pathway
REACT_15334
DARPP-32 events pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_15307
Ca-dependent events pathway
REACT_9000
Calmodulin induced events pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
REACT_147694
DAP12 interactions pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04020
Calcium signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04210
Apoptosis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04310
Wnt signaling pathway pathway
hsa04340
Hedgehog signaling pathway pathway
hsa04540
Gap junction pathway
hsa04720
Long-term potentiation pathway
hsa04740
Olfactory transduction pathway
hsa04742
Taste transduction pathway
hsa04910
Insulin signaling pathway pathway
hsa04912
GnRH signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04916
Melanogenesis pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa04970
Salivary secretion pathway
hsa04971
Gastric acid secretion pathway
hsa04976
Bile secretion pathway
hsa05012
Parkinson's disease pathway
hsa05020
Prion diseases pathway
hsa05110
Vibrio cholerae infection pathway
hsa05146
Amoebiasis pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR signaling pathway
INOH website
Hedgehog signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
txa2pathway
Thromboxane A2 receptor signaling
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
aurora_a_pathway
Aurora A signaling
hdac_classi_pathway
Signaling events mediated by HDAC Class I
lkb1_pathway
LKB1 signaling events
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
shp2_pathway
SHP2 signaling
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
vegfr1_pathway
VEGFR1 specific signals
lpa4_pathway
LPA4-mediated signaling events
syndecan_1_pathway
Syndecan-1-mediated signaling events
Cross-References
SwissProt P17612
TrEMBL A0A024R7J0 K7EMV1
UniProt Splice Variant
Entrez Gene 5566
UniGene Hs.631630 Hs.712717 Hs.737973
RefSeq NM_002730 XM_005259984 NM_207518
HUGO HGNC:9380
OMIM 601639
CCDS CCDS12304 CCDS12305
HPRD 03382
IMGT
EMBL AC022098 AF208004 AF224718 AF239744 AK290147 BC039846 BC108259 CH471106 DQ667173 X07767
GenPept AAF75622 AAF76426 AAG35720 AAH39846 AAI08260 ABG25918 BAF82836 CAA30597 EAW84399 EAW84400
RNA Seq Atlas 5566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca