Homo sapiens Gene: NT5M
Summary
InnateDB Gene IDBG-32941.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5M
Gene Name 5',3'-nucleotidase, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205309
Encoded Proteins
5',3'-nucleotidase, mitochondrial
5',3'-nucleotidase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:17303335-17347663
Strand Forward strand
Band p11.2
Transcripts
ENST00000389022 ENSP00000373674
ENST00000478373 ENSP00000464303
ENST00000470418 ENSP00000463674
ENST00000483704 ENSP00000467567
ENST00000480529
ENST00000582909
ENST00000616989 ENSP00000481269
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0008252 nucleotidase activity
GO:0008253 5'-nucleotidase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006260 DNA replication
GO:0009223 pyrimidine deoxyribonucleotide catabolic process
GO:0009264 deoxyribonucleotide catabolic process
GO:0016311 dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046079 dUMP catabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyrimidine catabolism pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
Nicotinate and nicotinamide metabolism pathway
INOH
Nicotinate Nicotinamide metabolism pathway
Purine nucleotides nucleosides metabolism pathway
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513977
RefSeq NM_020201 XM_005256732 XM_005256737
HUGO
OMIM
CCDS CCDS32581
HPRD 12009
IMGT
EMBL
GenPept
RNA Seq Atlas