Homo sapiens Gene: DAZAP2
Summary
InnateDB Gene IDBG-33254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAZAP2
Gene Name DAZ associated protein 2
Synonyms PRTB;
Species Homo sapiens
Ensembl Gene ENSG00000183283
Encoded Proteins
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
DAZ associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:51238292-51271362
Strand Forward strand
Band q13.13
Transcripts
ENST00000425012 ENSP00000408251
ENST00000436900 ENSP00000404968
ENST00000412716 ENSP00000394699
ENST00000449723 ENSP00000412812
ENST00000439799 ENSP00000398804
ENST00000552173
ENST00000549555 ENSP00000448051
ENST00000551919
ENST00000549041
ENST00000549732 ENSP00000446554
ENST00000551534
ENST00000552459
ENST00000549497
ENST00000551313 ENSP00000447842
ENST00000604900 ENSP00000474597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369450 Hs.369761 Hs.621774
RefSeq NM_001136264 NM_001136266 NM_001136267 NM_001136268 NM_001136269 NM_014764
HUGO
OMIM
CCDS CCDS44884 CCDS44885 CCDS44886 CCDS44887 CCDS44888 CCDS8809
HPRD 08463
IMGT
EMBL
GenPept
RNA Seq Atlas