Version 5.4
Homo sapiens Gene: DAZAP2
Summary
InnateDB Gene IDBG-33254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAZAP2
Gene Name DAZ associated protein 2
Synonyms PRTB
Species Homo sapiens
Ensembl Gene ENSG00000183283
Encoded Proteins
IDBP-375149
DAZ associated protein 2
IDBP-375150
DAZ associated protein 2
IDBP-375151
DAZ associated protein 2
IDBP-375152
DAZ associated protein 2
IDBP-375155
DAZ associated protein 2
IDBP-600990
DAZ associated protein 2
IDBP-589173
DAZ associated protein 2
IDBP-583185
DAZ associated protein 2
IDBP-809868
DAZ associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:51238292-51271362
Strand Forward strand
Band q13.13
Transcripts
ENST00000425012 ENSP00000408251
ENST00000436900 ENSP00000404968
ENST00000412716 ENSP00000394699
ENST00000449723 ENSP00000412812
ENST00000439799 ENSP00000398804
ENST00000552173
ENST00000549555 ENSP00000448051
ENST00000551919
ENST00000549041
ENST00000549732 ENSP00000446554
ENST00000551534
ENST00000552459
ENST00000549497
ENST00000551313 ENSP00000447842
ENST00000604900 ENSP00000474597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000346
View Gene Order
ENSBTAG00000004349
Not yet available
Cross-References
SwissProt
TrEMBL S4R3Q0
UniProt Splice Variant
Entrez Gene 9802
UniGene
RefSeq NM_001136264 NM_001136266 NM_001136267 NM_001136268 NM_001136269 NM_014764
HUGO HGNC:2684
OMIM 607431
CCDS CCDS44884 CCDS44885 CCDS44886 CCDS44887 CCDS44888 CCDS8809
HPRD
IMGT
EMBL AC046135 AC139768
GenPept
RNA Seq Atlas 9802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca