Homo sapiens Gene: DKK2
Summary
InnateDB Gene IDBG-33265.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKK2
Gene Name dickkopf 2 homolog (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155011
Encoded Proteins
dickkopf homolog 2 (Xenopus laevis)
dickkopf homolog 2 (Xenopus laevis)
dickkopf homolog 2 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:106921802-107283806
Strand Reverse strand
Band q25
Transcripts
ENST00000285311 ENSP00000285311
ENST00000513208 ENSP00000421255
ENST00000510534
ENST00000510463 ENSP00000423797
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Wnt lrp6 signalling [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.211869 Hs.581804
RefSeq NM_014421
HUGO
OMIM
CCDS CCDS3675
HPRD 05658
IMGT
EMBL
GenPept
RNA Seq Atlas