|Homo sapiens Gene: PKN1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||protein kinase N1|
|Synonyms||DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1;|
protein kinase N1
protein kinase N1
|Useful resources||Stemformatics EHFPI ImmGen|
PKN1 is a ubiquitously expressed kinase that, when phosphorylated by TRAF1, plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 19:14433053-14471867|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Signaling mediated by p38-gamma and p38-delta
PAR1-mediated thrombin signaling events
RhoA signaling pathway
Regulation of Androgen receptor activity
|TrEMBL||K7EKY9 K7EL10 K7EM57 K7EN76|
|UniProt Splice Variant|
|EMBL||AC008569 AK123007 AK292130 AK313886 BC040061 BC094766 D26181 S75546 U33053|
|GenPept||AAB33345 AAC50209 AAH40061 AAH94766 BAA05169 BAF84819 BAG36611 BAG53845|
|RNA Seq Atlas||5585|