Homo sapiens Gene: RAD21
Summary
InnateDB Gene IDBG-33417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD21
Gene Name RAD21 homolog (S. pombe)
Synonyms CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1;
Species Homo sapiens
Ensembl Gene ENSG00000164754
Encoded Proteins
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
RAD21 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RAD21 is part of the cohesin complex which is the cellular machinery involved in sister chromatid cohesion and that which requires access to the nucleosomal DNA to perform its function in chromosome segregation.
Entrez Gene
Summary The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:116845935-116874866
Strand Reverse strand
Band q24.11
Transcripts
ENST00000297338 ENSP00000297338
ENST00000523986 ENSP00000428513
ENST00000517749 ENSP00000430273
ENST00000518055 ENSP00000428003
ENST00000520992 ENSP00000429342
ENST00000517485 ENSP00000427923
ENST00000523547
ENST00000519837 ENSP00000430524
ENST00000522699 ENSP00000428158
ENST00000519469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 301 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 301 [view]
Protein-Protein 300 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007131 reciprocal meiotic recombination
GO:0045087 innate immune response (InnateDB)
GO:0071168 protein localization to chromatin
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0016020 membrane
GO:0034991 nuclear meiotic cohesin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitotic Telophase/Cytokinesis pathway
Meiotic synapsis pathway
S Phase pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cohesin Loading onto Chromatin pathway
Cell Cycle, Mitotic pathway
Establishment of Sister Chromatid Cohesion pathway
Meiosis pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E5RG18
UniProt Splice Variant
Entrez Gene 5885
UniGene Hs.81848
RefSeq NM_006265
HUGO HGNC:9811
OMIM 606462
CCDS CCDS6321
HPRD 05924
IMGT
EMBL AC087350
GenPept
RNA Seq Atlas 5885