InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD21

Summary

InnateDB Gene

IDBG-33417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD21

Gene Name

RAD21 homolog (S. pombe)

Synonyms

CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1

Species

Homo sapiens

Ensembl Gene

ENSG00000164754

Encoded Proteins

IDBP-33419

RAD21 homolog (S. pombe)

IDBP-476616

RAD21 homolog (S. pombe)

IDBP-480521

RAD21 homolog (S. pombe)

IDBP-475756

RAD21 homolog (S. pombe)

IDBP-479768

RAD21 homolog (S. pombe)

IDBP-474819

RAD21 homolog (S. pombe)

IDBP-474533

RAD21 homolog (S. pombe)

IDBP-483904

RAD21 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12198550

RAD21 is part of the cohesin complex which is the cellular machinery involved in sister chromatid cohesion and that which requires access to the nucleosomal DNA to perform its function in chromosome segregation.

Entrez Gene

Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:116845935-116874866

Strand

Reverse strand

Band

q24.11

Transcripts

ENST00000297338	ENSP00000297338
ENST00000523986	ENSP00000428513
ENST00000517749	ENSP00000430273
ENST00000518055	ENSP00000428003
ENST00000520992	ENSP00000429342
ENST00000517485	ENSP00000427923
ENST00000523547
ENST00000519837	ENSP00000430524
ENST00000522699	ENSP00000428158
ENST00000519469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 301 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	301 [view]
Protein-Protein	300 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007131	reciprocal meiotic recombination
GO:0045087	innate immune response (InnateDB)
GO:0071168	protein localization to chromatin

Cellular Component

GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005829	cytosol
GO:0008278	cohesin complex
GO:0016020	membrane
GO:0034991	nuclear meiotic cohesin complex