InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS13

Summary

InnateDB Gene

IDBG-33655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS13

Gene Name

ribosomal protein S13

Synonyms

S13

Species

Homo sapiens

Ensembl Gene

ENSG00000110700

Encoded Proteins

IDBP-33657

ribosomal protein S13

IDBP-592006

ribosomal protein S13

IDBP-589956

ribosomal protein S13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:17074389-17077787

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000228140	ENSP00000228140
ENST00000531008
ENST00000531908
ENST00000526895
ENST00000525634	ENSP00000435777
ENST00000525828
ENST00000533969	ENSP00000432096
ENST00000527571
ENST00000534329
ENST00000528074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.

Experimentally validated
Total	151 [view]
Protein-Protein	149 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0033119	negative regulation of RNA splicing
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome