Homo sapiens Gene: KATNB1
Summary
InnateDB Gene IDBG-33756.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KATNB1
Gene Name katanin p80 (WD repeat containing) subunit B 1
Synonyms KAT;
Species Homo sapiens
Ensembl Gene ENSG00000140854
Encoded Proteins
katanin p80 (WD repeat containing) subunit B 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57735730-57757250
Strand Forward strand
Band q21
Transcripts
ENST00000379661 ENSP00000368982
ENST00000569018
ENST00000566785 ENSP00000457347
ENST00000566611
ENST00000566726 ENSP00000455270
ENST00000563462 ENSP00000457334
ENST00000563127
ENST00000562592 ENSP00000455350
ENST00000562542
ENST00000569627 ENSP00000457046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008568 microtubule-severing ATPase activity
GO:0045502 dynein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006605 protein targeting
GO:0007026 negative regulation of microtubule depolymerization
GO:0007079 mitotic chromosome movement towards spindle pole
GO:0010942 positive regulation of cell death
GO:0010976 positive regulation of neuron projection development
GO:0031117 positive regulation of microtubule depolymerization
GO:0051013 microtubule severing
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0008352 katanin complex
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.275675
RefSeq NM_005886 XM_006721123
HUGO
OMIM
CCDS CCDS10788
HPRD 04081
IMGT
EMBL
GenPept
RNA Seq Atlas