Homo sapiens Gene: NR4A1
Summary
InnateDB Gene IDBG-33982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR4A1
Gene Name nuclear receptor subfamily 4, group A, member 1
Synonyms GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3;
Species Homo sapiens
Ensembl Gene ENSG00000123358
Encoded Proteins
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
nuclear receptor subfamily 4, group A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52022832-52059507
Strand Forward strand
Band q13.13
Transcripts
ENST00000360284 ENSP00000353427
ENST00000243050 ENSP00000243050
ENST00000394825 ENSP00000378302
ENST00000394824 ENSP00000378301
ENST00000478250
ENST00000548977 ENSP00000456633
ENST00000546842 ENSP00000457070
ENST00000553200 ENSP00000456776
ENST00000545748 ENSP00000440864
ENST00000550082 ENSP00000449539
ENST00000549102
ENST00000547206
ENST00000550763 ENSP00000449858
ENST00000548232 ENSP00000449587
ENST00000548733
ENST00000550557
ENST00000550339
ENST00000550582 ENSP00000455767
ENST00000567890
ENST00000562373 ENSP00000455399
ENST00000565848
ENST00000564201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 122 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0030522 intracellular receptor signaling pathway
GO:0035767 endothelial cell chemotaxis
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TCR pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Gene Expression pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
Role of mef2d in t-cell apoptosis [Biocarta view]
PID NCI
RXR and RAR heterodimerization with other nuclear receptor
Glucocorticoid receptor regulatory network
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt P22736
TrEMBL H3BPN8
UniProt Splice Variant
Entrez Gene 3164
UniGene Hs.524430 Hs.614406 Hs.670088
RefSeq NM_001202233 NM_001202234 NM_002135 NM_173157 XM_005268822 XM_005268823 XM_005268824 XM_006719363 XM_006719364
HUGO HGNC:7980
OMIM 139139
CCDS CCDS55828 CCDS73471 CCDS8818
HPRD 00744
IMGT
EMBL AB307717 AC025259 AK297526 AK314437 BC016147 BT007144 CH471111 CR456704 D49728 D85245 HQ692855 L13740
GenPept AAA36763 AAH16147 AAP35808 ADZ17366 BAA08565 BAA12746 BAG37048 BAG59929 BAH02308 CAG32985 EAW58222 EAW58224 EAW58225
RNA Seq Atlas 3164