Homo sapiens Gene: EGF
Summary
InnateDB Gene IDBG-34100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGF
Gene Name epidermal growth factor
Synonyms HOMG4; URG;
Species Homo sapiens
Ensembl Gene ENSG00000138798
Encoded Proteins
epidermal growth factor
epidermal growth factor
epidermal growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:109912884-110012266
Strand Forward strand
Band q25
Transcripts
ENST00000265171 ENSP00000265171
ENST00000509793 ENSP00000424316
ENST00000503392 ENSP00000421384
ENST00000502723
ENST00000504633
ENST00000502579
ENST00000511228
ENST00000509996
ENST00000541061
ENST00000544918
ENST00000537316
ENST00000540840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001525 angiogenesis
GO:0002576 platelet degranulation
GO:0006260 DNA replication
GO:0007165 signal transduction
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007262 STAT protein import into nucleus
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030168 platelet activation
GO:0035413 positive regulation of catenin import into nucleus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043388 positive regulation of DNA binding
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0051048 negative regulation of secretion
GO:0060749 mammary gland alveolus development
GO:0070371 ERK1 and ERK2 cascade
GO:0090279 regulation of calcium ion import
GO:0090370 negative regulation of cholesterol efflux
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:2000008 regulation of protein localization to cell surface
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
EGFR1 pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
Response to elevated platelet cytosolic Ca2+ pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
EGFR downregulation pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
PLCG1 events in ERBB2 signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Focal adhesion pathway
Gap junction pathway
Regulation of actin cytoskeleton pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Non-small cell lung cancer pathway
INOH
GPCR signaling pathway
EGF signaling pathway pathway
PID BIOCARTA
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Mcalpain and friends in cell motility [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
Egf signaling pathway [Biocarta view]
PID NCI
Ceramide signaling pathway
Thromboxane A2 receptor signaling
Internalization of ErbB1
Signaling events mediated by PTP1B
ErbB1 downstream signaling
a6b1 and a6b4 Integrin signaling
EGFR-dependent Endothelin signaling events
Signaling events mediated by TCPTP
ErbB receptor signaling network
SHP2 signaling
Stabilization and expansion of the E-cadherin adherens junction
Arf6 signaling events
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.419815
RefSeq NM_001178130 NM_001178131 NM_001963 XM_005262799 XM_005262802
HUGO
OMIM
CCDS CCDS3689 CCDS54794 CCDS54795
HPRD 00578
IMGT
EMBL
GenPept
RNA Seq Atlas